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Licensed Unlicensed Requires Authentication Published by De Gruyter November 21, 2013

5-HT systems: emergent targets for memory formation and memory alterations

  • Alfredo Meneses

    PhD on Physiological sciences (1996) from UNAM. Postdoctoral stay in the NIA, USA 1997–1998. Currently, full Professor in the Department of Pharmacobiology of CINVESTAV. Expert Workshop “Further Understanding of Serotonin 7 Receptors’ Neuropsychopharmacology” (23rd September 2013, Rome). Projects referee: Neuroscience and Mental Health Board Medical Research Council, London UK (July 2006); Earth & Life Sciences Veni round 2012 (Holland). External Reviewer Research Foundation – Flanders (Fonds Wetenschappelijk Onderzoek – Vlaanderen, FWO), March 2013. External Reviewer: Career Development Awards Human Frontier Science Program Organization, Jan 2013.

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Abstract

Drugs acting through 5-hydroxytryptamine (serotonin or 5-HT) systems modulate memory and its alterations, although the mechanisms involved are poorly understood. 5-HT drugs may present promnesic and/or antiamnesic (or even being amnesic) effects. Key questions regarding 5-HT markers include whether receptors directly or indirectly participate and/or contribute to the physiological and pharmacological basis of memory and its pathogenesis; hence, the major aim of this article was to examine recent advances in emergent targets of the 5-HT systems for memory formation and memory alterations. Recent reviews and findings are summarized, mainly in the context of the growing notion of memory deficits in brain disorders (e.g., posttraumatic stress disorder, mild cognitive impairment, consumption of drugs, poststroke cognitive dysfunctions, schizophrenia, Parkinson disease, and infection-induced memory impairments). Mainly, mammalian and (some) human data were the focus. At least agonists and antagonists for 5-HT1A/1B, 5-HT2A/2B/2C, 5-HT3, 5-HT4, 5-HT6, and 5-HT7 receptors as well as serotonin uptake inhibitors seem to have a promnesic and/or antiamnesic effect in different conditions and 5-HT markers seem to be associated to neural changes. Available evidence offers clues about the possibilities, but the exact mechanisms remain unclear. For instance, 5-HT transporter expression seems to be a reliable neural marker related to memory mechanisms and its alterations.

Keywords: drugs; memory; serotonin

Corresponding author: Alfredo Meneses, Department of Pharmacobiology, CINVESTAV, Tenorios 235, Granjas Coapa, 14330 México City, México, e-mail:

About the author

Alfredo Meneses

PhD on Physiological sciences (1996) from UNAM. Postdoctoral stay in the NIA, USA 1997–1998. Currently, full Professor in the Department of Pharmacobiology of CINVESTAV. Expert Workshop “Further Understanding of Serotonin 7 Receptors’ Neuropsychopharmacology” (23rd September 2013, Rome). Projects referee: Neuroscience and Mental Health Board Medical Research Council, London UK (July 2006); Earth & Life Sciences Veni round 2012 (Holland). External Reviewer Research Foundation – Flanders (Fonds Wetenschappelijk Onderzoek – Vlaanderen, FWO), March 2013. External Reviewer: Career Development Awards Human Frontier Science Program Organization, Jan 2013.

I thank Sofia Meneses-Goytia for revised language and Roberto Gonzalez for his expert assistance. This work was supported, in part, by CONACYT grant 80060.

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Received: 2013-5-16
Accepted: 2013-9-29
Published Online: 2013-11-21
Published in Print: 2013-12-01

©2013 by Walter de Gruyter Berlin Boston

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