Abstract
Texaphyrins, first prepared by Sessler and coworkers in the 1980s, represent early examples of expanded porphyrins. This class of pentaaza, oligopyrrolic macrocycles demonstrates excellent tumor localization and metal-chelating properties. In biological milieus, texaphyrins act as redox mediators and are able to produce reactive oxygen species. Furthermore, texaphyrins have been shown to upregulate zinc in vivo, an important feature that inspired us to develop new zinc ionophores that might allow the same function to be elicited but via a simpler chemical means. In this review, the basic properties of texaphyrins and the zinc ionophores they helped spawn will be discussed in the cadre of developing an understanding that could lead to the preparation of new, redox-active anticancer agents.
This work was supported by the Cancer Prevention and Research Institute of Texas (CPRIT; grant RP 120393 to J.L.S.), the U.S. National Cancer Institute (grant CA 68682 to J.L.S.), and the Robert A. Welch Foundation (grant F-1018 to J.L.S.). All authors contributed either to the writing of this article or to the development of the original reports upon which it is based. The authors declare no competing financial interests. All authors have given approval to the final version of the manuscript.
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