Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter August 27, 2013

Natural products and the aging process

  • Volkan Ergin , Elif Burcu Bali , Reza Ebrahimi Hariry and Çimen Karasu EMAIL logo

Abstract

Literature surveys show that the most of the research that have been conducted on the effect of herbal remedies on many tissue pathologies, including metabolic disturbances, cardiovascular decline, neurodegeneration, cataract, diabetic retinopathy and skin inflammation, all lead to an accelerated aging process. The increased carbonylation of proteins (carbonyl stress) disturbing their function has been indicated as an underlying mechanism of cellular senescence and age-related diseases. Because it is also linked to the carbonyl stress, aging chronic disease and inflammation plays an important role in understanding the clinical implications of cellular stress response and relevant markers. Greater knowledge of the molecular and cellular mechanisms involved in several pathologies associated with aging would provide a better understanding to help us to develop suitable strategies, use specific targets to mitigate the effect of human aging, prevent particularly chronic degenerative diseases and improve quality of life. However, research is lacking on the herbal compounds affecting cellular aging signaling as well as studies regarding the action mechanism(s) of natural products in prevention of the age-related disease. This review provides leads for identifying new medicinal agents or potential phytochemical drugs from plant sources for the prevention or delaying cellular aging processes and the treatment of some disorders related with accelerated body aging.


Corresponding author: Prof. Dr. Çimen Karasu, Cellular Stress Response and Signal Transduction Research Laboratory, Faculty of Medicine, Department of Medical Pharmacology, Gazi University, Beşevler 06500, Ankara, Turkey, E-mail: ;

The authors acknowledge the support through the grants from the Scientific and Technical Research Council of Turkey (TUBITAK) (Project no. 106S025, 108S239, SBAG-3303), KOSGEB-2011–0850, Gazi University Research Foundation No: 01/2010–126, 01/2011–09, 01/2012–70, Ankara University Research Foundation, Project No: 10B336002 (2011), COST Action B35 (Lipid Peroxidation Associated Disorders: LPO), COST-BM1203 (EU-ROS). They also thank FARMASENS Biotech Co., Gazi University Techno Park, Ankara, Turkey, (www.farmasens.com) for their support to E. Burcu Bali as research assistant and LongAgeHealth Co., Ankara, Turkey.

References

1. Streit WJ, Xue QS. Alzheimer’s disease, neuroprotection, and CNS immunosenescence. Front Pharmacol 2012;3:1–7.Search in Google Scholar

2. Luo XG, Ding JQ, Chen SD. Microglia in the aging brain: relevance to neurodegeneration. Mol Neurodegener 2010;5:1–9.10.1186/1750-1326-5-12Search in Google Scholar PubMed PubMed Central

3. Harry GJ. Microglia during development and aging. Pharmacol Ther 2013;139:313–26.10.1016/j.pharmthera.2013.04.013Search in Google Scholar PubMed PubMed Central

4. Marín C, Yubero-Serrano EM, López-Miranda J, Pérez-Jiménez F. Endothelial aging associated with oxidative stress can be modulated by a healthy Mediterranean diet. Int J Mol Sci 2013;14:8869–89.10.3390/ijms14058869Search in Google Scholar PubMed PubMed Central

5. Barodka VM, Joshi BL, Berkowitz DE, Hogue CW Jr, Nyhan D. Review article: implications of vascular aging. Anesth Analg 2011;112:1048–60.10.1213/ANE.0b013e3182147e3cSearch in Google Scholar PubMed PubMed Central

6. Kawashima M, Ozawa Y, Shinmura K, Inaba T, Nakamura S, Kawakita T, Watanabe M, Tsubota K. Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders. Exp Gerontol 2013; in press.10.1016/j.exger.2013.04.002Search in Google Scholar PubMed

7. Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, Zouboulis CC. Skin anti-aging strategies. Dermatoendocrinol 2012;4:308–19.10.4161/derm.22804Search in Google Scholar PubMed PubMed Central

8. Samaras N, Samaras D, Frangos Lordos E, Forster A, Philippe J. A review of age related dehydroepiandrosterone (DHEA) decline and its association with well-known geriatric syndromes. Is treatment beneficial? Rejuvenation Res 2013; in press.10.1089/rej.2013.1425Search in Google Scholar PubMed PubMed Central

9. Junnila RK, List EO, Berryman DE, Murrey JW, Kopchick JJ. The GH/IGF-1 axis in ageing and longevity. Nat Rev Endocrinol 2013;9:366–76.10.1038/nrendo.2013.67Search in Google Scholar PubMed PubMed Central

10. Nesic DM, Stevanovic DM, Stankovic SD, Milosevic VL, Trajkovic V, Starcevic VP, Severs WB. Age-dependent modulation of central ghrelin effects on food intake and lipid metabolism in rats. Eur J Pharmacol 2013;710:85–91.10.1016/j.ejphar.2013.03.052Search in Google Scholar PubMed

11. Harman D. Free radical theory of aging: an update: increasing the functional life span. Ann N Y Acad Sci 2006;1067:10–21.10.1196/annals.1354.003Search in Google Scholar PubMed

12. Gruber J, Schaffer S, Halliwell B. The mitochondrial free radical theory of ageing–where do we stand? Front Biosci 2008;13:6554–79.10.2741/3174Search in Google Scholar PubMed

13. Höhn A, König J, Grune T. Protein oxidation in aging and the removal of oxidized proteins. J Proteomics 2013; in press.10.1016/j.jprot.2013.01.004Search in Google Scholar PubMed

14. Höhn A, Sittig A, Jung T, Grimm S, Grune T. Lipofuscinis formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts. Free Radic Biol Med 2012;1;53:1760–9.10.1016/j.freeradbiomed.2012.08.591Search in Google Scholar PubMed

15. Flanary BE, Streit WJ. Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes. Glia 2004;45:75–88.10.1002/glia.10301Search in Google Scholar PubMed

16. Flanary BE, Sammons NW, Nguyen C, Walker D, Streit WJ. Evidence that aging and amyloid promote microglial cell senescence. Rejuvenation Res 2007;10:61–74.10.1089/rej.2006.9096Search in Google Scholar PubMed

17. Streit WJ, Miller KR, Lopes KO, Njie E. Microglial degeneration in the aging brain–bad news for neurons? Front Biosci 2008;13:3423–38.10.2741/2937Search in Google Scholar PubMed

18. Murray DB, Haynes K, Tomita M. Redox regulation in respiring Saccharomyces cerevisiae. Biochim Biophys Acta 2011;1810:945–58.10.1016/j.bbagen.2011.04.005Search in Google Scholar PubMed

19. Cai Z, Yan LJ. Protein Oxidative modifications: beneficial roles in disease and health. J Biochem Pharmacol Res 2013;1:15–26.Search in Google Scholar

20. Ristow M, Zarse K. How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis). Exp Gerontol 2010;45:410–8.10.1016/j.exger.2010.03.014Search in Google Scholar PubMed

21. Ristow M, Schmeisser S. Extending life span by increasing oxidative stress. Free Radic Biol Med 2011;51:327–36.10.1016/j.freeradbiomed.2011.05.010Search in Google Scholar PubMed

22. Miyazawa T, Nakagawa K, Shimasaki S, Nagai R. Lipid glycation and protein glycation in diabetes and atherosclerosis. Amino Acids 2012;42:1163–70.10.1007/s00726-010-0772-3Search in Google Scholar PubMed

23. Negre-Salvayre A, Coatrieux C, Ingueneau C, Salvayre R. Advanced lipid per-oxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors. Br J Pharmacol 2008;153:6–20.10.1038/sj.bjp.0707395Search in Google Scholar PubMed PubMed Central

24. Ulrich P, Cerami A. Protein glycation, diabetes, and aging. Recent Prog Horm Res 2001;56:1–21.10.1210/rp.56.1.1Search in Google Scholar PubMed

25. Ramamurthy B, Larsson L. Detection of an aging-related increase in advanced glycation end products in fast- and slow-twitch skeletal muscles in the rat. Biogerontology 2013;14:293–301.10.1007/s10522-013-9430-ySearch in Google Scholar PubMed

26. Lo Pachin RM, Gavin T, Petersen DR, Barber DS. Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation. Chem Res Toxicol 2009;22:1499–508.10.1021/tx900147gSearch in Google Scholar PubMed PubMed Central

27. Karasu C. Glycoxidativestress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment. Open Cardiovasc Med J 2010;4:240–56.10.2174/1874192401004010240Search in Google Scholar PubMed PubMed Central

28. Baraibar MA, Liu L, Ahmed EK, Friguet B. Protein oxidative damage at the crossroads of cellular senescence, aging, and age-related diseases. Oxid Med Cell Longev 2012;2012:919832.10.1155/2012/919832Search in Google Scholar PubMed PubMed Central

29. Nakamura T, Cho DH, Lipton SA. Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases. Exp Neurol 2012;238:12–21.10.1016/j.expneurol.2012.06.032Search in Google Scholar PubMed PubMed Central

30. Liochev SI. Reactive oxygen species and the free radical theory of aging. Free Radic Biol Med 2013;60:1–4.10.1016/j.freeradbiomed.2013.02.011Search in Google Scholar PubMed

31. Baraibar MA, Ladouce R, Friguet B. Proteomic quantification and identification of carbonylated proteins upon oxidative stress and during cellular aging. J Proteomics 2013; in press.10.1016/j.jprot.2013.05.008Search in Google Scholar PubMed

32. Uribarri J, Cai W, Peppa M, Goodman S, Ferrucci L, Striker G, Vlassara H. Circulating glycotoxins and dietary advanced glycation end products: two links to inflammatory response, oxidative stress, and aging. J Gerontol A Biol Sci Med Sci 2007;62:427–33.10.1093/gerona/62.4.427Search in Google Scholar PubMed PubMed Central

33. Yanar K, Aydın S, Cakatay U, Mengi M, Buyukpınarbaşılı N, Atukeren P, Sitar ME, Sönmez A, Uslu E. Protein and DNA oxidation in different anatomic regions of rat brain in a mimetic ageing model. Basic Clin Pharmacol Toxicol 2011;109:423–33.10.1111/j.1742-7843.2011.00756.xSearch in Google Scholar

34. Sakul A, Cumaoğlu A, Aydin E, Ari N, Dilsiz N, Karasu C. Age- and diabetes-induced regulation of oxidative protein modification in rat brain and peripheral tissues: consequences of treatment with antioxidant pyridoindole. Exp Gerontol 2013;48:476–84.10.1016/j.exger.2013.02.028Search in Google Scholar

35. Cumaoglu A, Stefek M, Bauer V, Ari N, Aricioglu A, Karasu C. Glycoxidative and nitrosative stress in kidney of experimental diabetic rats: effects of the prydoindole antioxidant stobadine. Neuro Endocrinol Lett 2010;31:313–8.Search in Google Scholar

36. Hamelin M, Borot-Laloi C, Friguet B, Bakala H. Increased level of glycoxidation product N(epsilon)-(carboxymethyl)lysine in rat serum and urine proteins with aging: link with glycoxidative damage accumulation in kidney. Arch Biochem Biophys 2003;411:215–22.10.1016/S0003-9861(02)00735-XSearch in Google Scholar

37. Pekiner B, Ulusu NN, Das-Evcimen N, Sahilli M, Aktan F, Stefek M, Stolc S, Karasu C. Antioxidants in Diabetes-Induced Complications Study Group. In vivo treatment with stobadine prevents lipid peroxidation, protein glycation and calcium overload but does not ameliorate Ca2+ -ATPase activity in heart and liver of streptozotocin-diabetic rats: comparison with vitamin E. Biochim Biophys Acta 2002;1588:71–8.10.1016/S0925-4439(02)00141-2Search in Google Scholar

38. Cumaoğlu A, Ozansoy G, Irat AM, Arıcıoğlu A, Karasu C, Arı N. Effect of long term, non-cholesterol lowering dose of fluvastatin treatment on oxidative stress in brain and peripheral tissues of streptozotocin-diabetic rats. Eur J Pharmacol 2011;654:80–5.10.1016/j.ejphar.2010.11.035Search in Google Scholar PubMed

39. Ulusu NN, Sahilli M, Avci A, Canbolat O, Ozansoy G, Ari N, Bali M, Stefek M, Stolc S, Gajdosik A, Karasu C. Pentose phosphate pathway, glutathione-dependent enzymes and antioxidant defense during oxidative stress in diabetic rodent brain and peripheral organs: effects of stobadine and vitamin E. Neurochem Res 2003;28:815–23.10.1023/A:1023202805255Search in Google Scholar

40. Muteliefu G, Shimizu H, Enomoto A, Nishijima F, Takahashi M, Niwa T. Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelaminA through oxidative stress. Am J Physiol Cell Physiol 2012;303:C126–34.10.1152/ajpcell.00329.2011Search in Google Scholar PubMed

41. Cumaoglu A, Cevik C, Rackova L, Ari N, Karasu C. Effects of antioxidant stobadineon protein carbonylation, advanced oxidation protein products and reductive capacity of liver instreptozotocin-diabetic rats: role of oxidative/nitrosative stress. Biofactors 2007;30:171–8.10.1002/biof.5520300304Search in Google Scholar PubMed

42. Gradinaru D, Borsa C, Ionescu C, Margina D. Advanced oxidative and glycoxidative protein damage markers in the elderly with type 2 diabetes. J Proteomics 2013; in press.10.1016/j.jprot.2013.03.034Search in Google Scholar PubMed

43. Sebeková K, Klenovicsová K, Ferenczová J, Hedvig J, Podracká L, Heidland A. Advanced oxidation protein products and advanced glycation end products in children and adolescents with chronic renal insufficiency. J Ren Nutr 2012;22:143–8.10.1053/j.jrn.2011.10.022Search in Google Scholar PubMed

44. Song BJ, Abdelmegeed MA, Henderson LE, Yoo SH, Wan J, Purohit V, Hardwick JP, Moon KH. Increased nitroxidative stress promotes mitochondrial dysfunction in alcoholic and nonalcoholic Fatty liver disease. Oxid Med Cell Longev 2013;2013:781050.10.1155/2013/781050Search in Google Scholar PubMed PubMed Central

45. Jiao L, Taylor PR, Weinstein SJ, Graubard BI, Virtamo J, Albanes D, Stolzenberg-Solomon RZ. Advanced glycation end products, soluble receptor for advanced glycation end products, and risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 2011;20:1430–8.10.1158/1055-9965.EPI-11-0066Search in Google Scholar PubMed PubMed Central

46. Rahmadi A, Steiner N, Münch G. Advanced glycation end products as gerontotoxins and biomarkers for carbonyl-based degenerative processes in Alzheimer’s disease. Clin Chem Lab Med 2011;49:385–91.10.1515/CCLM.2011.079Search in Google Scholar PubMed

47. Fanelli F, Sepe S, D’Amelio M, Bernardi C, Cristiano L, Cimini A, Cecconi F, Ceru’ MP, Moreno S. Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease. Mol Neurodegener 2013;8:1–19.10.1186/1750-1326-8-8Search in Google Scholar PubMed PubMed Central

48. Tan KC, Shiu SW, Wong Y, Tam X. Serum advanced glycation end products (AGEs) are associated with insulin resistance. Diabetes Metab Res Rev 2011;27:488–92.10.1002/dmrr.1188Search in Google Scholar PubMed

49. Vlassara H, Striker G. Glycotoxins in the diet promotes diabetes and diabetic complications. Curr Diab Rep 2007;7:235–41.10.1007/s11892-007-0037-zSearch in Google Scholar PubMed

50. Babizhayev MA, Yegorov YE. Therapeutic uses of drug-carrier systems for imidazole-containing dipeptide compounds that act as pharmacological chaperones and have significant impact on the treatment of chronic diseases associated with increased oxidative stress and the formation of advanced glycation end products. Crit Rev Ther Drug Carrier Syst 2010;27:85–154.10.1615/CritRevTherDrugCarrierSyst.v27.i2.10Search in Google Scholar PubMed

51. Freund-Michel V, Guibert C, Dubois M, Courtois A, Marthan R, Savineau JP, Muller B. Reactive oxygen species as therapeutic targets in pulmonary hypertension. Ther Adv Respir Dis 2013;7:175–200.10.1177/1753465812472940Search in Google Scholar PubMed

52. Bartosz G. Reactive Oxygen Species, Antioxidants & aging: who is the Master & Who is the Servant? 2009;29:S1-11.Search in Google Scholar

53. Brieger K, Schiavone S, Miller FJ Jr, Krause KH. Reactive oxygen species: from health to disease. Swiss Med Wkly 2012;142:w13659.10.4414/smw.2012.13659Search in Google Scholar PubMed

54. Pi J, Collins S. Reactive oxygen species and uncoupling protein 2 in pancreatic β-cell function. Diabetes Obes Metab 2010;12(Suppl 2):141–8.10.1111/j.1463-1326.2010.01269.xSearch in Google Scholar PubMed

55. Račková L, Cumaoğlu A, Bağrıacık EU, Štefek M, Maechler P, Karasu Ç. Novel hexahydropyridoindole derivative as prospective agent against oxidative damage in pancreatic β cells. Med Chem 2011;7:711–7.10.2174/157340611797928370Search in Google Scholar

56. Cumaoğlu A, Ari N, Kartal M, Karasu Ç. Polyphenolic extracts from Olea europea L. protect against cytokine-induced β-cell damage through maintenance of redox homeostasis. Rejuvenation Res 2011;14:325–34.10.1089/rej.2010.1111Search in Google Scholar

57. Cumaoğlu A, Rackova L, Stefek M, Kartal M, Maechler P, Karasu C. Effects of olive leaf polyphenols against HO toxicity in insulin secreting β-cells. Acta Biochim Pol 2011;58:45–50.10.18388/abp.2011_2284Search in Google Scholar

58. Badía MC, Giraldo E, Dasí F, Alonso D, Lainez JM, Lloret A, Viña J. Reductive stress in young healthy individuals at risk of Alzheimer disease. Free Radic Biol Med 2013;63C:274–9.10.1016/j.freeradbiomed.2013.05.003Search in Google Scholar

59. Teodoro JS, Rolo AP, Palmeira CM. The NAD ratio redox paradox: why does too much reductive power cause oxidative stress? Toxicol Mech Methods 2013;23:297–302.10.3109/15376516.2012.759305Search in Google Scholar

60. Sajithlal GB, Chithra P, Chandrakasan G. Effect of curcuminon the advanced glycation and cross-linking of collagen in diabetic rats. Biochem Pharmacol 1998;56:1607–14.10.1016/S0006-2952(98)00237-8Search in Google Scholar

61. Yamaguchi F, Ariga T, Yoshimura Y, Nakazawa H. Antioxidative and anti-glycation activity of garcinol from Garcinia indica fruit rind. J Agric Food Chem 2000;48:180–5.10.1021/jf990845ySearch in Google Scholar PubMed

62. Kim HY, Kim K. Protein glycation inhibitory and antioxidative activities of some plant extracts in vitro. J Agric Food Chem 2003;51:1586–91.10.1021/jf020850tSearch in Google Scholar PubMed

63. Tung YT, Wu JH, Kuo YH, Chang ST. Antioxidant activities of natural phenolic compounds from Acacia confusa bark. Bioresour Technol 2007;98:1120–3.10.1016/j.biortech.2006.04.017Search in Google Scholar PubMed

64. Colín-González AL, Santana RA, Silva-Islas CA, Chánez-Cárdenas ME, Santamaría A, Maldonado PD. The antioxidant mechanisms underlying the aged garlic extract-and S-allylcysteine-induced protection. Oxid Med Cell Longev 2012;2012:907162.10.1155/2012/907162Search in Google Scholar PubMed PubMed Central

65. Du Y, Villeneuve NF, Wang XJ, Sun Z, Chen W, Li J, Lou H, Wong PK, Zhang DD. Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response. Environ Health Perspect 2008;116:1154–61.10.1289/ehp.11464Search in Google Scholar PubMed PubMed Central

66. Bahadoran Z, Mirmiran P, Azizi F. Potential efficacy of broccoli sprouts as a unique supplement for management of type 2 diabetes and its complications. J Med Food 2013;16:375–82.10.1089/jmf.2012.2559Search in Google Scholar PubMed

67. Amer J, Goldfarb A, Rachmilewitz EA, Fibach E. Fermented papaya preparation as redox regulator in blood cells of beta-thalassemic mice and patients. Phytother Res 2008;22:820–8.10.1002/ptr.2379Search in Google Scholar PubMed

68. Yamabe N, Kang KS, Goto E, Tanaka T, Yokozawa T. Beneficial effect of Corni Fructus, a constituent of Hachimi-jio-gan, on advanced glycation end-product-mediated renal injury in Streptozotocin-treated diabetic rats. Biol Pharm Bull 2007;30:520–6.10.1248/bpb.30.520Search in Google Scholar PubMed

69. Yülek F, Or M, Ozoğul C, Isik AC, Ari N, Stefek M, Bauer V, Karasu C. Effects of stobadine and vitamin E in diabetes-induced retinal abnormalities: involvement of oxidative stress. Arch Med Res 2007;38:503–11.10.1016/j.arcmed.2007.02.006Search in Google Scholar PubMed

70. Jang DS, Lee GY, Kim YS, Lee YM, Kim CS, Yoo JL, Kim JS. Anthraquinones from the seeds of Cassiatora with inhibitory activity on protein glycation and aldose reductase. Biol Pharm Bull 2007;30:2207–10.10.1248/bpb.30.2207Search in Google Scholar PubMed

71. Madsen-Bouterse SA, Kowluru RA. Oxidative stress and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Rev Endocr Metab Disord 2008;9:315–27.10.1007/s11154-008-9090-4Search in Google Scholar PubMed

72. Karasu C, Cumaoğlu A, Gürpinar AR, Kartal M, Kovacikova L, Milackova I, Stefek M. Aldose reductase inhibitory activity and antioxidant capacity of pomegranate extracts. Interdiscip Toxicol 2012;5:15–20.10.2478/v10102-012-0003-8Search in Google Scholar PubMed PubMed Central

73. Mesías M, Navarro M, Gökmen V, Morales FJ. Antiglycative effect of fruit and vegetable seed extracts: inhibition of AGE formation and carbonyl-trapping abilities. J Sci Food Agric 2013;93:2037–44.10.1002/jsfa.6012Search in Google Scholar PubMed

74. Zhu Q, Liang CP, Cheng KW, Peng X, Lo CY, Shahidi F, Chen F, Ho CT, Wang M. Trapping effects of green and black tea extracts on peroxidation-derived carbonyl substances of seal blubber oil. J Agric Food Chem 2009;57:1065–9.10.1021/jf802691kSearch in Google Scholar PubMed

75. Zhu Q, Zhang NQ, Lau CF, Chao J, Sun Z, Chang RC, Chen F, Wang M. In vitro attenuation of acrolein induced toxicity by phloretin, a phenolic compound from apple. Food Chem 2012;135:1762–8.10.1016/j.foodchem.2012.06.053Search in Google Scholar PubMed

76. Ippoushi K, Azuma K, Ito H, Horie H, Higashio H. [6]-Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions. Life Sci 2003;73:3427–37.10.1016/j.lfs.2003.06.022Search in Google Scholar PubMed

77. Relja B, Töttel E, Breig L, Henrich D, Schneider H, Marzi I, Lehnert M. Plant polyphenols attenuate hepatic injury after hemorrhage/resuscitation by inhibition of apoptosis, oxidative stress, and inflammation via NF-kappaB in rats. Eur J Nutr 2012;51:311–21.10.1007/s00394-011-0216-1Search in Google Scholar PubMed

78. Gacche RN, Dhole NA. Profile of aldose reductase inhibition, anti-cataract and free radical scavenging activity of selected medicinal plants: an attempt to standardize the botanicals for amelioration of diabetes complications. Food Chem Toxicol 2011;49:1806–13.10.1016/j.fct.2011.04.032Search in Google Scholar PubMed

79. Duraisamy Y, Gaffney J, Slevin M, Smith CA, Williamson K, Ahmed N. Aminosalicylic acid reduces the antiproliferative effect of hyperglycaemia, advanced glycation end products and glycated basic fibroblast growth factor in cultured bovine aortic endothelial cells: comparison with aminoguanidine. Mol Cell Biochem 2003;246:143–53.10.1023/A:1023470921116Search in Google Scholar

80. Xi M, Hai C, Tang H, Chen M, Fang K, Liang X. Antioxidant and antiglycation properties of total saponins extracted from traditional Chinese medicine used to treat diabetes mellitus. Phytother Res 2008;22:228–37.10.1002/ptr.2297Search in Google Scholar PubMed

81. Illien-Junger S, Grosjean F, Laudier DM, Vlassara H, Striker GE, Iatridis JC. Combined Anti-Inflammatory and Anti-AGE Drug Treatments Have a Protective Effect on Intervertebral Discs in Mice with Diabetes. PloS One 2013;8:e64302.10.1371/journal.pone.0064302Search in Google Scholar PubMed PubMed Central

82. Dong Q, Banaich MS, O’Brien PJ. Cytoprotection by almond skin extracts or catechins of hepatocyte cytotoxicity induced by hydroperoxide (oxidative stress model) versus glyoxal or methylglyoxal (carbonylationmodel). Chem Biol Interact 2010;185:101–9.10.1016/j.cbi.2010.03.003Search in Google Scholar PubMed

83. Perez Gutierrez RM. Inhibition of Advanced Glycation End-Product Formation by Origanum majorana L. In Vitro and in Streptozotocin-Induced Diabetic Rats. Evid Based Complement Alternat Med 2012;598638.10.1155/2012/598638Search in Google Scholar PubMed PubMed Central

84. Peng X, Cheng KW, Ma J, Chen B, Ho CT, Lo C, Chen F, Wang M. Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation end products. J Agric Food Chem 2008;56:1907–11.10.1021/jf073065vSearch in Google Scholar PubMed

85. Zhu Q, Zheng ZP, Cheng KW, Wu JJ, Zhang S, Tang YS, Sze KH, Chen J, Chen F, Wang M. Natural polyphenols as direct trapping agents of lipid peroxidation-derived acrolein and 4-hydroxy-trans-2-nonenal. ChemResToxicol 2009;22:1721–7.10.1021/tx900221sSearch in Google Scholar

86. Lo CY, Hsiao WT, Chen XY. Efficiency of trapping methylglyoxal by phenols and phenolic acids. J Food Sci 2011;76:H90–6.10.1111/j.1750-3841.2011.02067.xSearch in Google Scholar

87. Stefek M, Karasu C. Eye lens in aging and diabetes: effect of quercetin. Rejuvenation Res 2011;14:525–34.10.1089/rej.2011.1170Search in Google Scholar

88. Dogan I, Cumaoglu A, Aricioglu A, Ekmekci A. Inhibition of ErbB2 by herceptin reduces viability and survival, induces apoptosis and oxidative stress in Calu-3 cell line. Mol Cell Biochem 2011;347:41–51.10.1007/s11010-010-0610-7Search in Google Scholar

89. Programme schedule for SFRR-E Berlin supplement. Free Radical Res 2008;42:S98.10.1080/10715760802207914Search in Google Scholar

90. Cumaoglu A, Rackova L, Kartaland M, Karasu C. Effects of olive extracts on free radical metabolism and glucose stimulated insulin release in INS-1E cell line exposed to H2O2. FEBS J 2008;275(Suppl1):377.Search in Google Scholar

91. Kaneto H, Kajimoto Y, Miyagawa J, Matsuoka T, Fujitani Y, Umayahara Y, Hanafusa T, Matsuzawa Y, Yamasaki Y, Hori M. Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity. Diabetes 1999;48:2398–406.10.2337/diabetes.48.12.2398Search in Google Scholar

92. Lortz S, Tiedge M. Sequential inactivation of reactive oxygen species by combined overexpression of SOD isoforms and catalase in insulin-producing cells. Free Radic Biol Med 2003;34:683–8.10.1016/S0891-5849(02)01371-0Search in Google Scholar

93. Hamaoka R, Fujii J, Miyagawa J, Takahashi M, Kishimoto M, Moriwaki M, Yamamoto K, Kajimoto Y, Yamasaki Y, Hanafusa T, Matsuzawa Y, Taniguchi N. Overexpression of the aldose reductase gene induces apoptosis in pancreatic beta-cells by causing a redox imbalance. J Biochem 1999;126:41–7.10.1093/oxfordjournals.jbchem.a022434Search in Google Scholar PubMed

94. Huang M, Joseph JW. Metabolomic analysis of pancreatic β-cell insulin release in response to glucose. Islets 2012;4:210–22.10.4161/isl.20141Search in Google Scholar PubMed PubMed Central

95. Taylor-Fishwick DA. NOX, NOX Who is There? The Contribution of NADPH oxidase one to beta cell dysfunction. Front Endocrinol (Lausanne) 2013;4:1–8.10.3389/fendo.2013.00040Search in Google Scholar PubMed PubMed Central

96. Lu X, Liu J, Hou F, Liu Z, Cao X, Seo H, Gao B. Cholesterol induces pancreaticβ cell apoptosis through oxidative stress pathway. Cell Stress Chaperones 2011;16:539–48.10.1007/s12192-011-0265-7Search in Google Scholar PubMed PubMed Central

97. Chang KC, Hsu CC, Liu SH, Su CC, Yen CC, Lee MJ, Chen KL, Ho TJ, Hung DZ, Wu CC, Lu TH, Su YC, Chen YW, Huang CF. Cadmium induces apoptosis in pancreaticβ-cells through a mitochondria-dependent pathway: the role of oxidative stress-mediated c-Jun N-terminal kinase activation. PloS One 2013;8:e54374.10.1371/journal.pone.0054374Search in Google Scholar PubMed PubMed Central

98. Subramanian SL, Hull RL, Zraika S, Aston-Mourney K, Udayasankar J, Kahn SE. cJUNN-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets. Diabetologia 2012;55:166–74.10.1007/s00125-011-2338-7Search in Google Scholar PubMed PubMed Central

99. Lombardi A, Ulianich L, Treglia AS, Nigro C, Parrillo L, Lofrumento DD, Nicolardi G, Garbi C, Beguinot F, Miele C, DiJeso B. Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by anextra cellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway. Diabetologia 2012;55:141–53.10.1007/s00125-011-2315-1Search in Google Scholar PubMed

100. Ježek P, Dlasková A, Plecitá-Hlavatá L. Redox homeostasis in pancreatic β cells. Oxid Med Cell Longev 2012;2012:932838.10.1155/2012/932838Search in Google Scholar PubMed PubMed Central

101. Liu D, Pavlovic D, Chen MC, Flodström M, Sandler S, Eizirik DL. Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-). Diabetes 2000;49:1116–22.10.2337/diabetes.49.7.1116Search in Google Scholar PubMed

102. Azevedo-Martins AK, Lortz S, Lenzen S, Curi R, Eizirik DL, Tiedge M. Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappa B activation in insulin-producing cells. Diabetes 2003;52:93–101.10.2337/diabetes.52.1.93Search in Google Scholar PubMed

103. Padgett LE, Broniowska KA, Hansen PA, Corbett JA, Tse HM. The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis. Ann N Y Acad Sci 2013;1281:16–35.10.1111/j.1749-6632.2012.06826.xSearch in Google Scholar PubMed PubMed Central

104. Dai X, Ding Y, Zhang Z, Cai X, Li Y. Quercetin and quercitrin protect against cytokine induced injuries in RINm5F β-cells via the mitochondrial pathway and NF-κB signaling. Int J Mol Med 2013;31:265–71.10.3892/ijmm.2012.1177Search in Google Scholar PubMed

105. Ding Y, Zhang ZF, Dai XQ, Li Y (2012). Myricetin protects against cytokine-induced cell death in RIN-m5f β cells. J Med Food 2012;15:733–40.Search in Google Scholar

106. Lin CY, Ni CC, Yin MC, Lii CK. Flavonoids protect pancreatic beta-cells from cytokines mediated apoptosis through the activation of PI3-kinase pathway. Cytokine 2012;59:65–71.10.1016/j.cyto.2012.04.011Search in Google Scholar PubMed

107. Jang YJ, Kim J, Shim J, Kim J, Byun S, Oak MH, Lee KW, Lee HJ. Kaempferol attenuates 4-hydroxynonenal-induced apoptosis in PC12 cells by directly inhibiting NADPH oxidase. J Pharmacol Exp Ther 2011;337:747–54.10.1124/jpet.110.176925Search in Google Scholar

108. Rodríguez-Mañas L, El-Assar M, Vallejo S, López-Dóriga P, Solís J, Petidier R, Montes M, Nevado J, Castro M, Gómez-Guerrero C, Peiró C, Sánchez-Ferrer CF. Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation. Aging Cell 2009;8:226–38.10.1111/j.1474-9726.2009.00466.xSearch in Google Scholar

109. Barona J, Aristizabal JC, Blesso CN, Volek JS, Fernandez ML. Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. J Nutr 2012;142:1626–32.10.3945/jn.112.162743Search in Google Scholar

110. Landberg R, Naidoo N, van Dam RM. Diet and endothelial function: from individual components to dietary patterns. Curr Opin Lipidol 2012;23:147–55.10.1097/MOL.0b013e328351123aSearch in Google Scholar

111. Chong MF, Macdonald R, Lovegrove JA. Fruit polyphenols and CVD risk: a review of human intervention studies. Br J Nutr 2010;104(Suppl 3):S28–39.10.1017/S0007114510003922Search in Google Scholar

112. Ghosh D, Scheepens A. Vascular action of polyphenols. Mol Nutr Food Res 2009;53:322–31.10.1002/mnfr.200800182Search in Google Scholar

113. Mulvihill EE, Huff MW. Antiatherogenic properties of flavonoids: implications for cardiovascular health. Can J Cardiol 2010;26(Suppl A):17A–21A.10.1016/S0828-282X(10)71056-4Search in Google Scholar

114. Yubero-Serrano EM, Garcia-Rios A, Delgado-Lista J, Delgado-Casado N, Perez-Martinez P, Rodriguez-Cantalejo F, Fuentes F, Cruz-Teno C, Tunez I, Tasset-Cuevas I, Tinahones FJ, Perez-Jimenez F, Lopez-Miranda J. Postprandial effects of the Mediterranean diet on oxidant and antioxidant status in elderly men and women. J Am Geriatr Soc 2011;59:938–40.10.1111/j.1532-5415.2011.03381.xSearch in Google Scholar PubMed

115. Perez-Martinez P, Garcia-Quintana JM, Yubero-Serrano EM, Tasset-Cuevas I, Tunez I, Garcia-Rios A, Delgado-Lista J, Marin C, Perez-Jimenez F, Roche HM, Lopez-Miranda J. Postprandial oxidative stress is modified by dietary fat: evidence from a human intervention study. Clin Sci (Lond) 2010;119:251–61.10.1042/CS20100015Search in Google Scholar PubMed

116. Peña-Orihuela P, Camargo A, Rangel-Zuñiga OA, Perez-Martinez P, Cruz-Teno C, Delgado-Lista J, Yubero-Serrano EM, Paniagua JA, Tinahones FJ, Malagon MM, Roche HM, Perez-Jimenez F, Lopez-Miranda J. Antioxidant system response is modified by dietary fat in adipose tissue of metabolic syndrome patients. J Nutr Biochem 2013; in press.10.1016/j.jnutbio.2013.02.012Search in Google Scholar PubMed

117. Scoditti E, Calabriso N, Massaro M, Pellegrino M, Storelli C, Martines G, DeCaterina R, Carluccio MA. Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer. Arch Biochem Biophys 2012;527:81–9.10.1016/j.abb.2012.05.003Search in Google Scholar PubMed

118. Cruz-Teno C, Pérez-Martínez P, Delgado-Lista J, Yubero-Serrano EM, García-Ríos A, Marín C, Gómez P, Jiménez-Gómez Y, Camargo A, Rodríguez-Cantalejo F, Malagón MM, Pérez-Jiménez F, Roche HM, López-Miranda J. Dietary fat modifies the postprandial inflammatory state in subjects with metabolic syndrome: the LIPGENE study. Mol Nutr Food Res 2012;56:854–65.10.1002/mnfr.201200096Search in Google Scholar PubMed

119. Yubero-Serrano EM, Gonzalez-Guardia L, Rangel-Zuñiga O, Delgado-Casado N, Delgado-Lista J, Perez-Martinez P, Garcia-Rios A, Caballero J, Marin C, Gutierrez-Mariscal FM, Tinahones FJ, Villalba JM, Tunez I, Perez-Jimenez F, Lopez-Miranda J. Postprandial antioxidant gene expression is modified by Mediterranean diet supplemented with coenzyme in elderly men and women. Age (Dordr) 2013;35:159–70.10.1007/s11357-011-9331-4Search in Google Scholar PubMed PubMed Central

120. Aires DJ, Rockwell G, Wang T, Frontera J, Wick J, Wang W, Tonkovic-Capin M, Lu J, E L, Zhu H, Swerdlow RH. Potentiation of dietary restriction-induced lifespan extension by polyphenols. Biochim Biophys Acta 2012;1822:522–6.10.1016/j.bbadis.2012.01.005Search in Google Scholar PubMed PubMed Central

Received: 2013-6-25
Accepted: 2013-7-26
Published Online: 2013-08-27
Published in Print: 2013-12-01

©2013 by Walter de Gruyter Berlin Boston

Downloaded on 23.4.2024 from https://www.degruyter.com/document/doi/10.1515/hmbci-2013-0031/html
Scroll to top button