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Licensed Unlicensed Requires Authentication Published by De Gruyter May 29, 2015

A new procedure for the synthesis of 2-[(4-dodecyloxyphenyl)sulfonyl]butanoic acid

  • Yun-Long Shi , Ling Wang , Chao Qian , Ming Tao , Zu-Tai Liao and Xin-Zhi Chen EMAIL logo
From the journal Chemical Papers

Abstract

A new, practical and cost-effective route for scalable synthesis of 2-[(4-dodecyloxyphenyl)sulfonyl] butanoic acid, a key intermediate of a new cyan dye-forming coupler containing a sulfone group, was developed by adopting phenol as the starting material. The synthesis was accomplished in five steps with etherification, chlorosulfonation, reduction, nucleophilic reaction by C-S coupling and hydrolyzation. An important objective of the new synthetic route was the synthesis of 2-[4- (dodecyloxyphenyl)sulfonyl]butanoate. Overall yield obtained at optimized conditions increased to 66 %. The synthetic strategy was proven to be a process enabling rapid delivery of the target product with high purity.

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Received: 2015-1-11
Revised: 2015-3-17
Accepted: 2015-3-19
Published Online: 2015-5-29
Published in Print: 2015-9-1

© Institute of Chemistry, Slovak Academy of Sciences

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