Proposal for the use in emergency departments of cardiac troponins measured with the latest generation methods in patients with suspected acute coronary syndrome without persistent ST-segment elevation

Ivo Casagranda; Mario Cavazza; Aldo Clerico; Marcello Galvani; Filippo Ottani; Martina Zaninotto; Luigi Maria Biasucci; Gianfranco Cervellin; Tiziano Lenzi; Giuseppe Lippi; Mario Plebani; Marco Tubaro

doi:10.1515/cclm-2013-0423

Published by De Gruyter July 26, 2013

Proposal for the use in emergency departments of cardiac troponins measured with the latest generation methods in patients with suspected acute coronary syndrome without persistent ST-segment elevation

Ivo Casagranda , Mario Cavazza , Aldo Clerico , Marcello Galvani , Filippo Ottani , Martina Zaninotto , Luigi Maria Biasucci , Gianfranco Cervellin , Tiziano Lenzi , Giuseppe Lippi , Mario Plebani and Marco Tubaro

From the journal Clinical Chemistry and Laboratory Medicine

https://doi.org/10.1515/cclm-2013-0423

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Abstract

The purpose of this document is to develop recommendations on the use of the latest generation of cardiac troponins in emergency room settings for the diagnosis of myocardial infarction in patients with suspected acute coronary syndrome (ACS) without persistent ST-segment elevation (NSTE-ACS). The main points which have been addressed reaching a consensus are represented by:

Suitability and appropriateness of the terminology.
Appropriateness of the request.
Confirmation of the diagnosis of myocardial infarction (rule-in).
Exclusion of the diagnosis of myocardial infarction (rule-out).

Work method: Each point has been analyzed by taking into account the evidence presented in medical publications. Recommendations were developed using the criteria adopted by the European Society of Cardiology and the American Heart Association/American College of Cardiology (www.escardio.org/guidelines). Each point of the recommendation was submitted for validation to an external audit by a Group of Experts (named above).

Keywords: acute coronary syndrome; cardiac troponin; emergency departments; high-sensitivity assays; non-ST-segment elevation; 99th percentile

Corresponding author: Ivo Casagranda (coordinator), Emergency Department, Santi Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy

Published Online: 2013-07-26

Published in Print: 2013-09-01

Proposal for the use in emergency departments of cardiac troponins measured with the latest generation methods in patients with suspected acute coronary syndrome without persistent ST-segment elevation

Abstract

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