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Licensed Unlicensed Requires Authentication Published by De Gruyter September 8, 2015

Magnetic nanoparticles for magnetic drug targeting

  • Stefan Lyer , Raminder Singh , Rainer Tietze and Christoph Alexiou EMAIL logo

Abstract

Nanomedicine and superparamagnetic iron oxide nanoparticles (SPIONs) are thought to have an important impact on medicine in the future. Especially in cancer therapy, SPIONs offer the opportunity of improving the effectivity of the treatment and reduce side effects by magnetic accumulation of SPION-bound chemotherapeutics in the tumor area. Although still some challenges have to be overcome, before the new treatment concept of magnetic drug targeting will reach the patients, substantial progress has been made, and promising results were shown in the last years.


Corresponding author: Prof. Dr. med. Christoph Alexiou, University Hospital Erlangen, ENT-Department, Section of Experimental Oncology and Nanomedicine (SEON), Waldstraße 1, 91054 Erlangen, Germany. Phone: +49-9131-85-34769, Fax: +49-9131-85-34828, E-mail:

Acknowledgments

The authors would like to thank the German Research Foundation (DFG/AL552/3) for financial support.

References

[1] Al Faraj A, Shaik AP, Shaik AS. Magnetic single-walled carbon nanotubes as efficient drug delivery nanocarriers in breast cancer murine model: noninvasive monitoring using diffusion-weighted magnetic resonance imaging as sensitive imaging biomarker. Int J Nanomed 2015; 10: 157–168.Search in Google Scholar

[2] Alexiou C, Diehl D, Henninger P, et al. A high field gradient magnet for magnetic drug targeting. IEEE Trans Appl Supercond 2006; 16: 1527–1530.10.1109/TASC.2005.864457Search in Google Scholar

[3] Alexiou C, Schmidt A, Klein R, Hulin P, Bergemann C, Arnold W. Magnetic drug targeting: biodistribution and dependency on magnetic field strength. J Magn Magn Mater 2002; 252: 363–366.10.1016/S0304-8853(02)00605-4Search in Google Scholar

[4] Alexiou C, Tietze R, Schreiber E, et al. Cancer therapy with drug loaded magnetic nanoparticles-magnetic drug targeting. J Magn Magn Mater 2011; 323: 1404–1407.10.1016/j.jmmm.2010.11.059Search in Google Scholar

[5] Amara D, Felner I, Nowik I, Margel S. Synthesis and characterization of Fe and Fe3O4 nanoparticles by thermal decomposition of triiron dodecacarbonyl. Colloids Surf A Physicochem Eng Asp 2009; 339: 106–110.10.1016/j.colsurfa.2009.02.003Search in Google Scholar

[6] Arruebo M, Fernandez-Pacheco R, Ibarra MR, Santamaria J. Magnetic nanoparticles for drug delivery. Nano Today 2007; 2: 22–32.10.1016/S1748-0132(07)70084-1Search in Google Scholar

[7] Avdeev MV, Bica D, Vekas L, et al. On the possibility of using short chain length mono-carboxylic acids for stabilization of magnetic fluids. J Magn Magn Mater 2007; 311: 6–9.10.1016/j.jmmm.2006.11.155Search in Google Scholar

[8] Ayres LR, de Almeida Campos MS, de Oliveira Gozzo T, et al. Trastuzumab induced cardiotoxicity in HER2 positive breast cancer patients attended in a tertiary hospital. Int J Clin Pharm 2015; 37: 365–372.10.1007/s11096-015-0070-ySearch in Google Scholar

[9] Babincova M, Altanerova V, Altaner C, Bergemann C, Babinec P. In vitro analysis of cisplatin functionalized magnetic nanoparticles in combined cancer chemotherapy and electromagnetic hyperthermia. IEEE Trans Nanobioscience 2008; 7: 15–19.10.1109/TNB.2008.2000145Search in Google Scholar

[10] Bica D, Vekas L, Avdeev MV, et al. Sterically stabilized water based magnetic fluids: synthesis, structure and properties. J Magn Magn Mater 2007; 311: 17–21.10.1016/j.jmmm.2006.11.158Search in Google Scholar

[11] Brigger I, Dubernet C, Couvreur P. Nanoparticles in cancer therapy and diagnosis. Adv Drug Deliv Rev 2002; 54: 631–651.10.1016/S0169-409X(02)00044-3Search in Google Scholar

[12] Bruners P, Braunschweig T, Hodenius M, et al. Thermoablation of malignant kidney tumors using magnetic nanoparticles: an in vivo feasibility study in a rabbit model. Cardiovasc Interv Radiol 2010; 33: 127–134.10.1007/s00270-009-9583-xSearch in Google Scholar

[13] Cao QL, Han XT, Li LA. Enhancement of the efficiency of magnetic targeting for drug delivery: development and evaluation of magnet system. J Magn Magn Mater 2011; 323: 1919–1924.10.1016/j.jmmm.2010.11.058Search in Google Scholar

[14] Chen Q, Rondinone AJ, Chakoumakos BC, Zhang ZJ. Synthesis of superparamagnetic MgFe2O4 nanoparticles by coprecipitation. J Magn Magn Mater 1999; 194: 1–7.10.1016/S0304-8853(98)00585-XSearch in Google Scholar

[15] Cherry EM, Eaton JK. A comprehensive model of magnetic particle motion during magnetic drug targeting. Int J Multiphas Flow 2014; 59: 173–185.10.1016/j.ijmultiphaseflow.2013.11.007Search in Google Scholar

[16] Cherry EM, Maxim PG, Eaton JK. Particle size, magnetic field, and blood velocity effects on particle retention in magnetic drug targeting. Med Phys 2010; 37: 175–182.10.1118/1.3271344Search in Google Scholar PubMed

[17] Chertok B, Moffat BA, David AE, et al. Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors. Biomaterials 2008; 29: 487–496.10.1016/j.biomaterials.2007.08.050Search in Google Scholar PubMed PubMed Central

[18] Danhier F, Feron O, Preat V. To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J Control Release 2010; 148: 135–146.10.1016/j.jconrel.2010.08.027Search in Google Scholar PubMed

[19] David AE, Cole AJ, Chertok B, Park YS, Yang VC. A combined theoretical and in vitro modeling approach for predicting the magnetic capture and retention of magnetic nanoparticles in vivo. J Control Release 2011; 152: 67–75.10.1016/j.jconrel.2011.01.033Search in Google Scholar PubMed PubMed Central

[20] Durr S, Janko C, Lyer S, et al. Magnetic nanoparticles for cancer therapy. Nanotechnol Rev 2013; 2: 395–409.10.1515/ntrev-2013-0011Search in Google Scholar

[21] Dutz S, Andrae W, Hergt R, et al. Influence of dextran coating on the magnetic behaviour of iron oxide nanoparticles. J Magn Magn Mater 2007; 311: 51–54.10.1016/j.jmmm.2006.11.168Search in Google Scholar

[22] Dutz S, Kettering M, Hilger I, Muller R, Zeisberger M. Magnetic multicore nanoparticles for hyperthermia-influence of particle immobilization in tumour tissue on magnetic properties. Nanotechnology 2011; 22(26): 265102–265109.10.1088/0957-4484/22/26/265102Search in Google Scholar PubMed

[23] Eberbeck D, Bergemann C, Hartwig S, Steinhoff U, Trahms L. Binding kinetics of magnetic nanoparticles on latex beads and yeast cells studied by magnetorelaxometry. J Magn Magn Mater 2005; 289: 435–438.10.1016/j.jmmm.2004.11.122Search in Google Scholar

[24] Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer 2013; 49: 1374–1403.10.1016/j.ejca.2012.12.027Search in Google Scholar PubMed

[25] Fortin JP, Wilhelm C, Servais J, Menager C, Bacri JC, Gazeau F. Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia. J Am Chem Soc 2007; 129: 2628–2635.10.1021/ja067457eSearch in Google Scholar PubMed

[26] Georgiadou V, Kokotidou C, Le Droumaguet B, Carbonnier B, Choli-Papadopoulou T, Dendrinou-Samara C. Oleylamine as a beneficial agent for the synthesis of CoFe(2)O(4) nanoparticles with potential biomedical uses. Dalton Trans (Cambridge, England: 2003) 2014; 43: 6377–6388.10.1039/C3DT53179ASearch in Google Scholar

[27] Gitter K, Odenbach S. Quantitative targeting maps based on experimental investigations for a branched tube model in magnetic drug targeting. J Magn Magn Mater 2011; 323: 3038–3042.10.1016/j.jmmm.2011.06.055Search in Google Scholar

[28] Gitter K, Odenbach S. Investigations on a branched tube model in magnetic drug targeting-systematic measurements and simulation. IEEE Trans Magn 2013; 49: 343–348.10.1109/TMAG.2012.2224324Search in Google Scholar

[29] Gleich B, Hellwig N, Bridell H, et al. Design and evaluation of magnetic fields for nanoparticle drug targeting in cancer. IEEE Trans Nanotechnol 2007; 6:164–170.10.1109/TNANO.2007.891829Search in Google Scholar

[30] Globocan 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. [http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx].Search in Google Scholar

[31] Gunduz U, Keskin T, Tansik G, et al. Idarubicin-loaded folic acid conjugated magnetic nanoparticles as a targetable drug delivery system for breast cancer. Biomed Pharmacother 2014; 68: 729–736.10.1016/j.biopha.2014.08.013Search in Google Scholar PubMed

[32] Gupta AK, Gupta M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 2005; 26: 3995–4021.10.1016/j.biomaterials.2004.10.012Search in Google Scholar PubMed

[33] Gupta AK, Wells S. Surface-modified superparamagnetic nanoparticles for drug delivery: Preparation, characterization, and cytotoxicity studies. IEEE Trans Nanobioscience 2004; 3: 66–73.10.1109/TNB.2003.820277Search in Google Scholar

[34] Hajshafiei P, Fatahian S, Shahanipoor K. In vivo toxicity assessment of bovine serum albumin and dimercaptosuccinic acid coated Fe3O4 nanoparticles. Iran J Biotech 2014; 12: e16858.10.5812/ijb.16858Search in Google Scholar

[35] Han XT, Cao QL, Li L. Design and evaluation of three-dimensional electromagnetic guide system for magnetic drug delivery. IEEE Trans Appl Supercond 2012; 22: 4401404–4401408.10.1109/TASC.2011.2176456Search in Google Scholar

[36] Harisinghani MG, Barentsz J, Hahn PF, et al. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med 2003; 348: 2491–2499.10.1056/NEJMoa022749Search in Google Scholar PubMed

[37] Heidsieck A, Vosen S, Zimmermann K, Wenzel D, Gleich B. Analysis of trajectories for targeting of magnetic nanoparticles in blood vessels. Mol Pharm 2012; 9: 2029–2038.10.1021/mp3001155Search in Google Scholar PubMed

[38] Heilmaier C, Lutz AM, Bolog N, Weishaupt D, Seifert B, Willmann JK. Focal liver lesions: detection and characterization at double-contrast liver MR imaging with ferucarbotran and gadobutrol versus single-contrast liver MR imaging. Radiology 2009; 253: 724–733.10.1148/radiol.2533090161Search in Google Scholar PubMed

[39] Hilton JE, McMurry SM. An adjustable linear Halbach array. J Magn Magn Mater 2012; 324: 2051–2056.10.1016/j.jmmm.2012.02.014Search in Google Scholar

[40] Huang X, Yi C, Fan Y, et al. Magnetic Fe(3) O (4) nanoparticles grafted with single-chain antibody (scFv) and docetaxel loaded beta-cyclodextrin potential for ovarian cancer dual-targeting therapy. Mater Sci Engineering C Mater Biol Appl 2014; 42: 325–332.10.1016/j.msec.2014.05.041Search in Google Scholar PubMed

[41] Huang ZY, Pei N, Wang YY, et al. Deep magnetic capture of magnetically loaded cells for spatially targeted therapeutics. Biomaterials 2010; 31: 2130–2140.10.1016/j.biomaterials.2009.11.062Search in Google Scholar PubMed

[42] Hwu JR, Lin YS, Josephrajan T, et al. Targeted Paclitaxel by conjugation to iron oxide and gold nanoparticles. J Am Chem Soc 2009; 131: 66–68.10.1021/ja804947uSearch in Google Scholar PubMed

[43] Jalalian SH, Taghdisi SM, Hamedani NS, et al. Epirubicin loaded super paramagnetic iron oxide nanoparticle-aptamer bioconjugate for combined colon cancer therapy and imaging in vivo. Eur J Pharm Sci 2013; 50: 191–197.10.1016/j.ejps.2013.06.015Search in Google Scholar

[44] Jordan A, Scholz R, Wust P, et al. Endocytosis of dextran and silan-coated magnetite nanoparticles and the effect of intracellular hyperthermia on human mammary carcinoma cells in vitro. J Magn Magn Mater 1999; 194: 185–196.10.1016/S0304-8853(98)00558-7Search in Google Scholar

[45] Jurgons R, Seliger C, Hilpert A, Trahms L, Odenbach S, Alexiou C. Drug loaded magnetic nanoparticles for cancer therapy. J Phys Condens Matter 2006; 18: S2893–S2902.10.1088/0953-8984/18/38/S24Search in Google Scholar

[46] Khalafalla SE, Reimers GW. Preparation of dilution-stable aqueous magnetic fluids. IEEE Trans Magn 1980; 16: 178–183.10.1109/TMAG.1980.1060578Search in Google Scholar

[47] Khanna RA, Anger C. Patterns of patients stopping their anti-cancer drug due to its associated side effects in France, Germany, Italy, Spain and UK (EU5). In: ESMO 2014. Spain: Madrid, 2014.Search in Google Scholar

[48] Khatiri R, Reyhani A, Mortazavi SZ, Hossainalipour M. Immobilization of serum albumin on the synthesized three layers core-shell structures of super-paramagnetic iron oxide nanoparticles. J Ind Eng Chem 2013; 19: 1642–1647.10.1016/j.jiec.2013.02.002Search in Google Scholar

[49] Khodadust R, Unsoy G, Gunduz U. Development of poly (I:C) modified doxorubicin loaded magnetic dendrimer nanoparticles for targeted combination therapy. Biomed Pharmacother 2014; 68: 979–987.10.1016/j.biopha.2014.10.009Search in Google Scholar

[50] Kim YI, Kim D, Lee CS. Synthesis and characterization of CoFe2O4 magnetic nanoparticles prepared by temperature-controlled coprecipitation method. Physica B Condens Matter 2003; 337: 42–51.10.1016/S0921-4526(03)00322-3Search in Google Scholar

[51] Kohler N, Sun C, Wang J, Zhang MQ. Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells. Langmuir 2005; 21: 8858–8864.10.1021/la0503451Search in Google Scholar PubMed

[52] Kratz H, Eberbeck D, Wagner S, Taupitz M, Schnorr J. Synthetic routes to magnetic nanoparticles for MPI. Biomed Eng-Biomed Tech 2013; 58: 509–515.10.1515/bmt-2012-0057Search in Google Scholar PubMed

[53] Laurent S, Dutz S, Hafeli UO, Mahmoudi M. Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles. Adv Colloid Interfac 2011; 166: 8–23.10.1016/j.cis.2011.04.003Search in Google Scholar PubMed

[54] Laurent S, Saei AA, Behzadi S, Panahifar A, Mahmoudi M. Superparamagnetic iron oxide nanoparticles for delivery of therapeutic agents: opportunities and challenges. Exp Opin Drug Deliv 2014; 11: 1449–1470.10.1517/17425247.2014.924501Search in Google Scholar PubMed

[55] Lee IJ, Ahn CH, Cha EJ, Chung IJ, Chung JW, Kim YI. Improved drug targeting to liver tumors after intra-arterial delivery using superparamagnetic iron oxide and iodized oil preclinical study in a rabbit model. Invest Radiol 2013; 48: 826–833.10.1097/RLI.0b013e31829c13efSearch in Google Scholar PubMed

[56] Lin M, Huang J, Sha M. Recent advances in nanosized Mn-Zn ferrite magnetic fluid hyperthermia for cancer treatment. J Nanosci Nanotechnol 2014; 14: 792–802.10.1166/jnn.2014.9135Search in Google Scholar PubMed

[57] Lonning PE, Knappskog S. Mapping genetic alterations causing chemoresistance in cancer: identifying the roads by tracking the drivers. Oncogene 2013; 32: 5315–5330.10.1038/onc.2013.48Search in Google Scholar PubMed

[58] Lyer S, Tietze R, Duerr S, et al. Diagnostic imaging in cancer therapy with magnetic nanoparticles. In: Buzug B, editor. 2nd workshop on magnetic particle imaging IWMPI 2012. Lübeck: Springer 2012: 197–201.Search in Google Scholar

[59] Lyer S, Tietze R, Jurgons R, et al. Distribution of magnetic nanoparticles after magnetic drug targeting in an ex vivo bovine artery model. In: Dössel O, editor. World Congress 2009. Munich: SWC 2009: 484–487.10.1007/978-3-642-03885-3_134Search in Google Scholar

[60] Lyer S, Tietze R, Jurgons R, et al. Visualisation of tumour regression after local chemotherapy with magnetic nanoparticles – a pilot study. Anticancer Res 2010; 30: 1553–1557.Search in Google Scholar

[61] Maity D, Kale SN, Kaul-Ghanekar R, Xue JM, Ding J. Studies of magnetite nanoparticles synthesized by thermal decomposition of iron (III) acetylacetonate in tri(ethylene glycol). J Magn Magn Mater 2009; 321: 3093–3098.10.1016/j.jmmm.2009.05.020Search in Google Scholar

[62] Majd MH, Asgari D, Barar J, et al. Specific targeting of cancer cells by multifunctional mitoxantrone-conjugated magnetic nanoparticles. J Drug Target 2013; 21: 328–340.10.3109/1061186X.2012.750325Search in Google Scholar PubMed

[63] Matuszak J, Zaloga J, Friedrich RP, et al. Endothelial biocompatibility and accumulation of SPION under flow conditions. J Magn Magn Mater 2015; 380: 20–26.10.1016/j.jmmm.2014.09.005Search in Google Scholar

[64] Mehta DA, Hay JW. Cost-effectiveness of adding bevacizumab to first line therapy for patients with advanced ovarian cancer. Gynecol Oncol 2014; 132: 677–683.10.1016/j.ygyno.2014.01.021Search in Google Scholar PubMed

[65] Meidanchi A, Akhavan O, Khoei S, Shokri AA, Hajikarimi Z, Khansari N. ZnFe2O4 nanoparticles as radiosensitizers in radiotherapy of human prostate cancer cells. Mater Sci Eng C Mater Biol Appl 2015; 46: 394–399.10.1016/j.msec.2014.10.062Search in Google Scholar PubMed

[66] Nacev A, Komaee A, Sarwar A, et al. Towards control of magnetic fluids in patients directing therapeutic nanoparticles to disease locations. IEEE Control Syst Mag 2012; 32: 32–74.10.1109/MCS.2012.2189052Search in Google Scholar

[67] Orel V, Shevchenko A, Romanov A, et al. Magnetic properties and antitumor effect of nanocomplexes of iron oxide and doxorubicin. Nanomedicine 2015; 11: 47–55.10.1016/j.nano.2014.07.007Search in Google Scholar PubMed

[68] Pankhurst QA, Connolly J, Jones SK, Dobson J. Applications of magnetic nanoparticles in biomedicine. J Phys D Appl Phys 2003; 36: R167–R181.10.1088/0022-3727/36/13/201Search in Google Scholar

[69] Pereira C, Pereira AM, Fernandes C, et al. Superparamagnetic MFe2O4 (M=Fe, Co, Mn) nanoparticles: tuning the particle size and magnetic properties through a novel one-step coprecipitation route. Chem Mater 2012; 24: 1496–1504.10.1021/cm300301cSearch in Google Scholar

[70] Pernia Leal M, Rivera-Fernandez S, Franco JM, Pozo D, de la Fuente JM, Garcia-Martin ML. Long-circulating PEGylated manganese ferrite nanoparticles for MRI-based molecular imaging. Nanoscale 2015; 7: 2050–2059.10.1039/C4NR05781CSearch in Google Scholar

[71] Popovici E, Dumitrache F, Morjan I, et al. Iron/iron oxides core-shell nanoparticles by laser pyrolysis: structural characterization and enhanced particle dispersion. Appl Surf Sci 2007; 254: 1048–1052.10.1016/j.apsusc.2007.09.022Search in Google Scholar

[72] Rahn H, Gomez-Morilla I, Jurgons R, Alexiou C, Eberbeck D, Odenbach S. Tomographic examination of magnetic nanoparticles used as drug carriers. J Magn Magn Mater 2009; 321: 1517–1520.10.1016/j.jmmm.2009.02.078Search in Google Scholar

[73] Rahn H, Odenbach S. X-ray microcomputed tomography as a tool for the investigation of the biodistribution of magnetic nanoparticles. Nanomedicine 2009; 4: 981–990.10.2217/nnm.09.82Search in Google Scholar PubMed

[74] Rajpure KY. Exploring structural and magnetic properties of nanocrystalline iron oxide synthesized by autocombustion method. Superlattices Microstruct 2015; 77: 181–195.10.1016/j.spmi.2014.11.012Search in Google Scholar

[75] Ramesh R, Ponnusamy S, Muthamizhchelvan C. Synthesis, properties and heating characteristics of bovine serum albumin coated Fe3O4 magnetic fluid for magnetic fluid hyperthermia application. Sci Adv Mater 2013; 5: 1250–1255.10.1166/sam.2013.1579Search in Google Scholar

[76] Rao YF, Chen W, Liang XG, et al. Epirubicin-loaded superparamagnetic iron-oxide nanoparticles for transdermal delivery: cancer therapy by circumventing the skin barrier. Small. Germany: Weinheim an der Bergstrasse 2015; 11: 239–247.Search in Google Scholar

[77] Richter H, Wiekhorst F, Schwarz K, et al. Magnetorelaxometric quantification of magnetic nanoparticles in an artery model after ex vivo magnetic drug targeting. Phys Med Biol 2009; 54: N417–N424.10.1088/0031-9155/54/18/N03Search in Google Scholar PubMed

[78] Sadighian S, Rostamizadeh K, Hosseini-Monfared H, Hamidi M. Doxorubicin-conjugated core-shell magnetite nanoparticles as dual-targeting carriers for anticancer drug delivery. Colloids Surf B Biointerfaces 2014; 117: 406–413.10.1016/j.colsurfb.2014.03.001Search in Google Scholar PubMed

[79] Santra S, Tapec R, Theodoropoulou N, Dobson J, Hebard A, Tan WH. Synthesis and characterization of silica-coated iron oxide nanoparticles in microemulsion: The effect of nonionic surfactants. Langmuir 2001; 17: 2900–2906.10.1021/la0008636Search in Google Scholar

[80] Sarwar A, Nemirovski A, Shapiro B. Optimal Halbach permanent magnet designs for maximally pulling and pushing nanoparticles. J Magn Magn Mater 2012; 324: 742–754.10.1016/j.jmmm.2011.09.008Search in Google Scholar PubMed PubMed Central

[81] Scharlach C, Kratz H, Wiekhorst F, et al. Synthesis of acid-stabilized iron oxide nanoparticles and comparison for targeting atherosclerotic plaques: evaluation by MRI, quantitative MPS, and TEM alternative to ambiguous Prussian blue iron staining. Nanomedicine 2015; 11: 1085–1095.10.1016/j.nano.2015.01.002Search in Google Scholar PubMed

[82] Schuetz CA, Juillerat-Jeanneret L, Mueller H, Lynch I, Riediker M. NanoImpactNet C: therapeutic nanoparticles in clinics and under clinical evaluation. Nanomedicine 2013; 8: 449–467.10.2217/nnm.13.8Search in Google Scholar PubMed

[83] Seliger C, Jurgons R, Wiekhorst F, et al. In vitro investigation of the behaviour of magnetic particles by a circulating artery model. J Magn Magn Mater 2007; 311: 358–362.10.1016/j.jmmm.2006.10.1205Search in Google Scholar

[84] Singh A, Sahoo SK. Magnetic nanoparticles: a novel platform for cancer theranostics. Drug Discov Today 2014; 19: 474–481.10.1016/j.drudis.2013.10.005Search in Google Scholar PubMed

[85] Singh D, McMillan JM, Kabanov AV, Sokolsky-Papkov M, Gendelman HE. Bench-to-bedside translation of magnetic nanoparticles. Nanomedicine (London, England) 2014; 9: 501–516.10.2217/nnm.14.5Search in Google Scholar

[86] Tehrani MD, Kim MO, Yoon J. A novel electromagnetic actuation system for magnetic nanoparticle guidance in blood vessels. IEEE Trans Magn 2014; 50: 5100412–5100423.10.1109/TMAG.2014.2307271Search in Google Scholar

[87] Tian Y, Jiang X, Chen X, Shao Z, Yang W. Doxorubicin-loaded magnetic silk fibroin nanoparticles for targeted therapy of multidrug-resistant cancer. Adv Mater (Deerfield Beach, Fla) 2014; 26: 7393–7398.10.1002/adma.201403562Search in Google Scholar PubMed

[88] Tietze R, Jurgons R, Lyer S, et al. Quantification of drug-loaded magnetic nanoparticles in rabbit liver and tumor after in vivo administration. J Magn Magn Mater 2009; 321: 1465–1468.10.1016/j.jmmm.2009.02.068Search in Google Scholar

[89] Tietze R, Lyer S, Durr S, et al. Efficient drug-delivery using magnetic nanoparticles – biodistribution and therapeutic effects in tumour bearing rabbits. Nanomed-Nanotechnol 2013; 9: 961–971.10.1016/j.nano.2013.05.001Search in Google Scholar PubMed

[90] Tietze R, Rahn H, Lyer S, et al. Visualization of superparamagnetic nanoparticles in vascular tissue using X mu CT and histology. Histochem Cell Biol 2011; 135: 153–158.10.1007/s00418-011-0780-8Search in Google Scholar PubMed

[91] Tietze R, Schreiber E, Lyer S, Alexiou C. Mitoxantrone loaded superparamagnetic nanoparticles for drug targeting: a versatile and sensitive method for quantification of drug enrichment in rabbit tissues using HPLC-UV. J Biomed Biotechnol 2010; 2010: 597304.10.1155/2010/597304Search in Google Scholar PubMed PubMed Central

[92] Tombacz E, Bica D, Hajdu A, Illes E, Majzik A, Vekas L. Surfactant double layer stabilized magnetic nanofluids for biomedical application. J Phys Condens Matter 2008; 20: 204103.10.1088/0953-8984/20/20/204103Search in Google Scholar PubMed

[93] Unsoy G, Khodadust R, Yalcin S, Mutlu P, Gunduz U. Synthesis of Doxorubicin loaded magnetic chitosan nanoparticles for pH responsive targeted drug delivery. Eur J Pharm Sci 2014; 62: 243–250.10.1016/j.ejps.2014.05.021Search in Google Scholar PubMed

[94] Unterweger H, Tietze R, Janko C, et al. Development and characterization of magnetic iron oxide nanoparticles with a cisplatin-bearing polymer coating for targeted drug delivery. Int J Nanomed 2014; 9: 3659–3676.10.2147/IJN.S63433Search in Google Scholar PubMed PubMed Central

[95] Wiekhorst F, Liebl M, Steinhoff U, et al. Magnetorelacometry for in-vivo quantification of magnetic nanoparticle distributions after magnetic drug targeting in a rabbit carcinoma model. In: Buzug editor. 2nd international workshop on magnetic particle imaging IWMPI 2012; Lübeck, Germany: Springer; 2012: 301–305.10.1007/978-3-642-24133-8_48Search in Google Scholar

[96] Yang G, Zhang BL, Wang J, Xie SB, Li X. Preparation of polylysine-modified superparamagnetic iron oxide nanoparticles. J Magn Magn Mater 2015; 374: 205–208.10.1016/j.jmmm.2014.08.040Search in Google Scholar

[97] Yang GX, He F, Lv RC, et al. A cheap and facile route to synthesize monodisperse magnetic nanocrystals and their application as MRI agents. Dalton Trans 2015; 44: 247–253.10.1039/C4DT02425GSearch in Google Scholar PubMed

[98] Ye H, Tong J, Wu J, et al. Preclinical evaluation of recombinant human IFN alpha(2)b-containing magnetoliposomes for treating hepatocellular carcinoma. Int J Nanomed 2014; 9: 4533–4550.Search in Google Scholar

[99] Zaloga J, Janko C, Nowak J, et al. Development of a lauric acid/albumin hybrid iron oxide nanoparticle system with improved biocompatibility. Int J Nanomed 2014; 9: 4847–4866.10.2147/IJN.S68539Search in Google Scholar PubMed PubMed Central

[100] Zhang SP, Dong DW, Sui Y, et al. Preparation of core shell particles consisting of cobalt ferrite and silica by sol-gel process. J Alloys Compd 2006; 415: 257–260.10.1016/j.jallcom.2005.07.048Search in Google Scholar

[101] Zou Y, Liu P, Liu CH, Zhi XT. Doxorubicin-loaded mesoporous magnetic nanoparticles to induce apoptosis in breast cancer cells. Biomed Pharmacother 2015; 69: 355–360.10.1016/j.biopha.2014.12.012Search in Google Scholar PubMed

Received: 2015-3-11
Accepted: 2015-8-5
Published Online: 2015-9-8
Published in Print: 2015-10-1

©2015 by De Gruyter

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