[Bis(3-ammonium-1-hydroxypropylidene-1,1-bisphosphonato)iron(II)]: TheFe2+ Salt ofPamidronate, a Clinically Effective Diphosphonate Ligand

Khalid Abu-Shandi; Christoph Janiak

doi:10.1515/znb-2005-1206

Open Access Published by De Gruyter June 2, 2014

[Bis(3-ammonium-1-hydroxypropylidene-1,1-bisphosphonato)iron(II)]: TheFe²⁺ Salt ofPamidronate, a Clinically Effective Diphosphonate Ligand

Khalid Abu-Shandi and Christoph Janiak

From the journal Zeitschrift für Naturforschung B

https://doi.org/10.1515/znb-2005-1206

The solvent-free title compound ²_∞[Fe^II{H₃N₊CH₂CH₂C(OH)(PO₃H⁻)(PO₃H⁻)}₂] was prepared by hydrothermal synthesis and consists of (4,4)-nets of iron octahedra (as the nodes) linked by corner sharing tetrahedra of the phosphonate groups. These layers are stacked in an ABB’A’ sequence and are connected to give a three-dimensional network by hydrogen bonds between the non-Fe-bridging phosphonate groups. Pamidronate, C₃H₁₀NO₇P₂⁻ is a zwitterion with an overall charge of −1.

Keywords: Iron(II); Diphosphonate; Pamidronate; Hydrogen Bonding; Hydrothermal Synthesis

Received: 2005-9-22

Published Online: 2014-6-2

Published in Print: 2005-12-1

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

[Bis(3-ammonium-1-hydroxypropylidene-1,1-bisphosphonato)iron(II)]: TheFe²⁺ Salt ofPamidronate, a Clinically Effective Diphosphonate Ligand

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