A simple and efficient protocol is described for the regioselective hydrolysis of terminal isopropylidene ketal protection in carbohydrate derivatives 1a - 11a. It uses either CoCl2 · 2H2O in acetonitrile or InCl3 in methanol at temperatures ranging from 50 to 60 °C. The low cost of CoCl2·2H2O along with its requirement in catalytic quantities offers a great advantage for the multi-gram scale reaction.
Received: 2005-3-2
Published Online: 2014-6-2
Published in Print: 2005-9-1
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