Open Access, Peer-reviewed
pISSN 2508-4887
eISSN 2508-4895
    Korean J Perinatol. 2015 Jun;26(2):121-127. Korean.
    Published online Jun 30, 2015.
    https://doi.org/10.14734/kjp.2015.26.2.121
    Copyright © 2015 The Korean Society of Perinatology
    Original Article

    Clinical Characteristics of Meconium Aspiration Syndrome according to Ventilator Care

    Ryoung-Kyoung Lim, M.D., Mi-hye Bae, M.D., Ah-Young Kim, M.D., Young-Mi Han, M.D., Kyung-Hee Park, M.D. and Shin-Yun Byun, M.D.
      • Department of Pediatrics, Pusan National University School of Medicine, Yangsan, Korea.
    • Correspondence to: Shin-Yun Byun, M.D. Department of Pediatrics, Pusan National University Children's Hospital, 20 Geumo-ro, Mulgeum-eup, Yangsan 626-770, Korea. Tel: +82-55-360-2180, Fax: +82-55-360-2181, Email: byun410@hanmail.net
    Received April 02, 2015; Revised June 10, 2015; Accepted June 11, 2015.

    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Abstract

    Purpose

    Meconium aspiration syndrome is an important cause of neonatal morbidity and mortality, and sometimes patients need mechanical ventilator therapy. The aim of this study was to identify the risk factors which required mechanical ventilation.

    Methods

    We retrospectively analyzed 44 infants diagnosed as meconium aspiration syndrome from January 2009 to December 2013. We divided into 2 groups (ventilator group and oxygen therapy group) and analyzed the clinical characteristics, vital signs, laboratory findings and clinical courses.

    Results

    Ventilator group and oxygen therapy group included each 22 infants, and there were no significant differences in clinical characteristics between two groups. Time to transfer and time to start oxygen therapy were longer in ventilator group but not statistical difference. Initial mean blood pressure and pH were significantly lower in ventilator group than in oxygen therapy group (P=0.026, P=0.003). Ventilator group had longer treatment period and worse prognosis than oxygen therapy group.

    Conclusion

    If the infants with meconium aspiration and respiratory distress represent low pH and hypotension, we have to pay close attention to early oxygen supplementation and proper treatment to prevent poor clinical course.

    Keywords
    Meconium aspiration syndrome; Ventilator care; Risk factors

    Tables

    Table 1
    Clinical Characteristics and Initial Vital Signs of Patients

    Table 2
    Initial Laboratory Finding of Patients

    Table 3
    Clinical Course of Patients

    Notes

    This study was supported by a 2013 research grant from Pusan National University Yangsan Hospital.

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    MeSH Terms
    Blood Pressure
    Humans
    Hydrogen-Ion Concentration
    Hypotension
    Infant
    Infant, Newborn
    Meconium Aspiration Syndrome*
    Mortality
    Oxygen
    Prognosis
    Respiration, Artificial
    Retrospective Studies
    Risk Factors
    Ventilators, Mechanical*
    Vital Signs
    Metrics
    Share
    Tables
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    Funding Information
    PERMALINK