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Abstract
Primary Epstein-Barr virus (EBV) infection can manifest with a broad spectrum of neurological complications. There are only rare reports of Guillain-Barré syndrome (GBS) supervening on meningitis in patients with primary EBV infection. Clear evidence of central nervous system in-fection makes it difficult for the clinicians to consider a diagnosis of GBS. We present a patient with GBS supervening on meningitis in primary EBV infection.
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Fig. 1.
(A) Leptomeningeal enhancement was found in contrast-enhanced T1-weighted brain magnetic resonance imaging (MRI) with no parenchymal lesion. The findings of T2-weighted brain MRI were unremarkable. (B) No spinal cord lesion was evident in cervical, thoracic, and lumbar spine MRI.
Table 1.
Epstein-Barr virus serological profiles
| VCA IgM | VCA IgG | EBNA IgG | EBV DNA PCR (serum) | EBV DNA PCR (CSF) | |
|---|---|---|---|---|---|
| On admission | Serum | EBV DNA PCR | Positive | Positive | Positive |
| Three weeks from symptom onset | CSF | Positive | Positive | Negative | Negative |
Table 2.
Electrophysiological findings
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