Abstract
Androgen blockage, with either orchiectomy or luteinizing hormone releasing hormone (LHRH) analogs combined with an antiandrogen drug, is the standard treatment for metastatic prostate cancer. Flutamide is a nonsteroidal antiandrogen drug that is frequently used for total androgen blockage. We report on a 54-yr-old man with metastatic prostate cancer who developed nonoliguric acute renal failure (ARF) during treatment with flutamide. Following discontinuation of flutamide therapy, his renal functions returned to normal limits within 4 wk. After a rechallenge with flutamide, serum levels of BUN and creatinine increased again. His renal function recovered completely after the cessation of the drug for the second time. This observation confirm that ARF may be clearly attributed to flutamide therapy. Although very rare, flutamide-induced ARF should be considered.
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References
Crawford, E.D., Mario, A., Eisenberger, M.A., David, G., McLeod, D.G., Joseph, T., et al. (1989). A controlled trial of leuprolide with and without flutamide in prostate carcinoma. N. Engl. J. Med. 321:419–424.
Cetin, M., Demirci, D., Unal, A., Altmbas, M., Guven, M. and Unluhizarci, K. (1999). Frequency of flutamide induced hepatotoxicity in patients with prostate carcinoma. Hum; Exp. Toxicol. 18:137–140.
Fossa, D.S., Slee, P.H., Brausi, M., Horenblas, S., Hall, R.R., Hetherigton, J.W., et al. (2001). Flutamide versus prednisone in patients with prostate cancer symptomatically progressing after androgen-ablative therapy: a phase III study of the european organization for research and treatment of cancer genitourinary group. J. Clin. Oncol. 19:62–71.
Boccardo, F., Rubagotti, A., Barichello, M., Battaglia, M., Carmignani, G., Comeri, G., et al. (1999). Bicalutamide monotherapy versus flutamide plus goserelin in prostate cancer petients: results of an Italian prostate cancer project study. J. Clin. Oncol. 17:2027–2038.
Paul, A.B., Love, C. and Chisholm, G.D. (1994). The management of bilateral ureteric obstruction and renal failure in advanced prostate cancer. Br. J. Urol. 74:642–645.
Smith, A., Harbour, D. and Liebman, J. (1997). Acute renal failure in a patient receiving treatment with suramin. Am. J. Clin. Oncol. 20:433–434.
Figg, W.D., Cooper, M.R., Thibault, A., Headlee, D., Humphrey, J., Bergan, R.C., et al. (1994). Acute renal toxicity associated with suramin in the treatment of prostate cancer. Cancer 74:1612–1614.
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Altiparmak, M.R., Bilici, A., Kisacik, B. et al. Flutamide-induced acute renal failure in a patient with metastatic prostate cancer. Med Oncol 19, 117–119 (2002). https://doi.org/10.1385/MO:19:2:117
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DOI: https://doi.org/10.1385/MO:19:2:117