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Autoimmune modulation of astrocyte-mediated homeostasis

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Abstract

Astrocytes are principal mediators of homeostasis in the central nervous system (CNS). They supply neurons and oligodendrocytes with substrates for energy metabolism and clear the extracellular space of excess neurotransmitters. In neuroinflammation, astrocytes have classically been regarded as unimportant since their capacity to present antigen to T cells is limited and has been questioned in vivo. However, it is an evolving concept that autoimmunity in the CNS has a profound impact on astrocytes. In this review, we focus on the alterations in astrocyte functions that occur during an autoimmune attack of the CNS.

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  1. Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA

    Thomas Korn

  2. Neurologische Universitätsklinik, Homburg (Saart), Germany

    Thomas Korn & Tim Magnus

  3. Stem Cell Section, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD

    Mahendra Rao & Tim Magnus

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Korn, T., Rao, M. & Magnus, T. Autoimmune modulation of astrocyte-mediated homeostasis. Neuromol Med 9, 1–15 (2007). https://doi.org/10.1385/NMM:9:1:1

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