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Brain temperature and outcome after severe traumatic brain injury

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Abstract

Introduction

In humans, raised body temperature is linked to poor outcome after brain injury. Because deviations between brain and body temperature have been reported after severe traumatic brain injury (TBI), the aim of this study was to explore the relationship between initial and mean brain temperature and survival at 3 months.

Methods

Intraparenchymal temperature was measured 3–4 cm within white matter. Logistic regression was used to explore linear and quadratic relationships between initial and average brain temperature and survival at 3 months.

Results

In 36 patients, initial brain temperatures ranged from 33.5 to 39.2°C (median 37.4°C). There was no evidence of an association between initial brain temperature and risk of death, either linear (odds ratio [OR] 95% confidence interval [CI]=1.3 [0.68 to 2.5], p=0.42) or quadratic (p=0.26). Assuming a linear relationship, patients with higher mean brain temperatures were less likely to die: OR (95% CI) for death per 1°C was 0.31 (0.09 to 1.1), p=0.06. However, by fitting the quadratic relationship, there was a suggestion that both high and low temperatures were associated with increased risk of death: p=0.06.

Conclusion

Initial brain temperature measured shortly after adminission did not predict outcome. There is a suggestion that patients with “middle range” temperatures were less likely to die.

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Authors and Affiliations

  1. Division of Medicine and Neurosciences, University of Manchester, Hope Hospital, Eccles Old Road, M68HD, Salford, UK

    Charmaine Childs & Timothy Rainey

  2. Biostatistics Group, University of Manchester, Hope Hospital, Eccles Old Road, M68HD, Salford, UK

    Andy Vail

  3. Department of Neurosurgery, University of Manchester, Hope Hospital, Eccles Old Road, M68HD, Salford, UK

    Paul Leach

  4. Intensive Care Medicine, University of Manchester, Hope Hospital, Eccles Old Road, M68HD, Salford, UK

    Richard Protheroe

  5. Clinical Director and Consultant Neurosurgeon, University of Manchester, Hope Hospital, Eccles Old Road, M68HD, Salford, UK

    Andrew King

Authors
  1. Charmaine Childs
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  2. Andy Vail
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  3. Paul Leach
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  4. Timothy Rainey
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  5. Richard Protheroe
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  6. Andrew King
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Correspondence to Charmaine Childs.

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Childs, C., Vail, A., Leach, P. et al. Brain temperature and outcome after severe traumatic brain injury. Neurocrit Care 5, 10–14 (2006). https://doi.org/10.1385/NCC:5:1:10

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