Abstract
We here describe the transporter classification (TC) system that provides a rational means of classifying all transmembrane transport systems found in living organisms. The availability of this system provides a framework for the use of bioinformatic technologies to answer fundamental questions about the functions, mechanisms, and evolutionary pathways taken for the appearance of these systems. Such advances are discussed.
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Saier, M. H., Jr. (1998) Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya, in Advances in Microbial Physiology (Poole, R. K., ed.), Academic, San Diego, CA, pp. 81–136.
Saier, M. H., Jr. (1999) Genome archeology leading to the characterization and classification of transport proteins. Curr. Opin. Microbiol. 2, 555–561.
Saier, M. H., Jr. (2000) A functional-phylogenetic classification system for transmembrane solute transporters. Microbiol. Mol. Biol. Rev. 64, 354–411.
Saier, M. H., Jr. (2000) Vectorial metabolism and the evolution of transport systems. J. Bacteriol. 182, 5029–5035.
Saier, M. H., Jr. (2001) Evolution of transport proteins. In Genetic Engineering. Principles and Methods, vol. 23 (J. K. Setlow, ed.), Kluwer Academic/Plenum, New York, pp. 1–10.
Busch, W. and Saier, M. H., Jr. (2002) The Transporter Classification (TC) System, 2002, Crit. Rev. Biochem. Mol. Biol. 37, 287–337.
Saier, M. H., Jr. (1994) Computer-aided analyses of transport protein sequences: gleaning evidence concerning function, structure, biogenesis, and evolution. Microbiol. Rev. 58, 71–93.
Saier, M. H., Jr. and Tseng, T. -T. (1999) Evolutionary origins of transmembrane transport systems. In Transport of Molecules Across Microbial Membranes, Symposium 58, Society for General Microbiology (Broome-Smith, J. K., Baumberg, S., Stirling, C. J., et al., eds.), Cambridge University Press, Cambridge, UK, pp. 252–274.
Saier, M. H., Jr. (2000) Families of proteins forming transmembrane channels. J. Membr. Biol. 175, 165–180.
Zhai, Y. and Saier, M. H., Jr. (2001) A web-based program (WHAT) for the simultaneous prediction of hydropathy, amphipathicity, secondary structure and transmembrane topology for a single protein sequence. J. Mol. Microbiol. Biotechnol. 4, 501–502.
Claros, M. G. and von Heijne, G. (1994) TopPred II: An improved software for membrane protein structure predictions. CABIOS 10, 685–686.
Saier, M. H., Jr. and Kollman, J. (1999) Is FatP a long chain fatty acid transporter? Mol. Microbiol. 33, 670–672.
Faergeman, N. J., Black, P. N., Zhao, X. D., et al. (2001) The acyl-CoA synthetases encoded within FAA1 and FAA4 in Saccharomyces cerevisiae function as components of the fatty acid transport system linking import, activation, and intracellular utilization. J. Biol. Chem. 276, 37051–37059.
C. elegans Sequencing Consortium. (1998) Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 282, 2012–2017.
Pei, J. and Grishin, N. V. (2001) AL2CO: calculation of positional conservation in a protein sequence alignment. Bioinformatics 17, 700–712.
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Busch, W., Saier, M.H. The IUBMB-endorsed transporter classification system. Mol Biotechnol 27, 253–262 (2004). https://doi.org/10.1385/MB:27:3:253
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DOI: https://doi.org/10.1385/MB:27:3:253