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Tau function and dysfunction in neurons

Its role in neurodegenerative disorders

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Abstract

Alzheimer’s disease (AD) is the most usual neurodegenerative disorder leading to dementia in the aged human population. It is characterized by the presence of two main brain pathological hallmarks: senile plaques and neurofibrillary tangles (NFTs). NFTs are composed of fibrillar polymers of the abnormally phosphorylated cytoskeletal protein tau.

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  1. Centro de Biología Molecular (CSIC-UAM), Universidad Autónoma, 28049, Madrid, Spain

    Jesús Ávila, Filip Lim, Francisco Moreno & A. Claudio Cuello

  2. Instituto de Neurociencias, Universidad Miguel Hernandez, Alicante, Spain

    Carlos Belmonte & A. Claudio Cuello

  3. Departments of Pharmacology and Therapeutics, Anatomy and Cell Biology; and Medicine, McGill University, 3655 Promenade Sir-William-Osler, H3G 1Y6, Montreal, QC, Canada

    A. Claudio Cuello

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Ávila, J., Lim, F., Moreno, F. et al. Tau function and dysfunction in neurons. Mol Neurobiol 25, 213–231 (2002). https://doi.org/10.1385/MN:25:3:213

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