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A short history of LIM domains (1993–2002)

From protein interaction to degradation

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Abstract

The LIM domain is a cysteine-rich zinc-finger motif found in a large family of proteins. In LIM-homeodomain (LIM-hd) transcription factors and LIM-only (LMO) factors, the LIM domains are responsible for key interactions with co-activators, co-repressors, competitors, and other transcription factors, and are therefore of considerable importance for the regulation of associated transcriptional activity. In this review, the authors describe the progressive discoveries of NLI/Ldb/CLIM, LMO and RLIM, and discuss how the field was very recently updated by the finding that LIM-hd transcriptional activity is controlled by regulated degradation of cofactors and LIM-hd themselves.

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  1. UPR 2197 “Développement, Evolution, Plasticité du Système Nerveux” Institut de Neurobiologie Alfred FESSARD, CNRS, Avenue de la Terrasse, 91198 GIF-sur, YVETTE cedex, France

    Sylvie Rétaux & Isabelle Bachy

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Rétaux, S., Bachy, I. A short history of LIM domains (1993–2002). Mol Neurobiol 26, 269–281 (2002). https://doi.org/10.1385/MN:26:2-3:269

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