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Genetic and pharmacological suppression of polyglutamine-dependent neuronal dysfunction in Caenorhabditis elegans

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Abstract

The identification of disease genes for several neurodegenerative illnesses has allowed for the development of disease models in experimental organisms. We discuss our approach to studying Huntington’s disease, the best characterized of the polyglutamine (polyQ) expansion disorders. We have developed a system in Caenorhabditis elegans to study the effects of (polyQ)-dependent neuronal dysfunction at the resolution of two neurons in screening for genetic and pharmacological suppression. Our data suggest that C. elegans might be instructive in searching for targets and active compounds against polyglutamine neuronal toxicity.

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  1. Laboratory of Genomic Biology, Inserm Avenir Group, Centre Paul Broca, 75014, Paris, France

    J. Alex Parker, Sébastien Holbert, Emmanuel Lambert, Salima Abderrahmane & Christian Néri

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  1. J. Alex Parker
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  2. Sébastien Holbert
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  3. Emmanuel Lambert
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  4. Salima Abderrahmane
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  5. Christian Néri
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Correspondence to Christian Néri.

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Parker, J.A., Holbert, S., Lambert, E. et al. Genetic and pharmacological suppression of polyglutamine-dependent neuronal dysfunction in Caenorhabditis elegans . J Mol Neurosci 23, 61–67 (2004). https://doi.org/10.1385/JMN:23:1-2:061

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