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Genes and genomics of autoimmune inflammation

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Abstract

Development of autoimmune diseases requires coordinated expression of a myriad of genes. To explore the spectrum and global patterns of gene expression during autoimmune inflammation, we have recently performed functional genomic studies of autoimmune inflammation in the central nervous system (CNS). Inflammation in the CNS not only induced the expression of many immune-related genes, but also signific antly altered the gene expression profile of neural cells. A number of unique clusters of genes were identified, which represent putative immune and nervous responses in autoimmune inflammation. This review will focus on two clusters of genes that we have been studying during the past few yeas; the Rel/nuclear factor (NF)-κB family and the tumor necrosis factor (TNF) family.

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References

  1. Cannody R, Hilliard B, Chodash L, Chen Y: FASEB J 2002;16: A243.8.

    Google Scholar 

  2. Beg AA, Baltimore D: Science 1996;274:782–784.

    Article  PubMed  CAS  Google Scholar 

  3. Beg AA, Sha WC, Bronso RT, Ghosh S, Baltimore D: Nature 1995;376:167–170.

    Article  PubMed  CAS  Google Scholar 

  4. Sha WC, Liou HC, Tuomanen EI, Baltimore D: Cell 1995;80:321–330.

    Article  PubMed  CAS  Google Scholar 

  5. Barnes PJ, Karin M: N Eng J Med 1997;336:1066–1071.

    Article  CAS  Google Scholar 

  6. Bull P, Morley KL, Hoekstra MF, Hunter T, Verma TM: Mol Cell Biol 1990;10:5473–5485.

    PubMed  CAS  Google Scholar 

  7. Bakalkin G, Yakovleva T, Terenius L: Brain Res Mol Brain Res 1993; 20:137–146.

    Article  PubMed  CAS  Google Scholar 

  8. Grumont RJ, Gerondakis S: Cell Growth Differ 1990;1:345–350.

    PubMed  CAS  Google Scholar 

  9. Grumon RJ, Gerondakis S: Oncogene Res 1990;5:245–254.

    Google Scholar 

  10. Brownell E, Mathieson B, Young HA, Keller J, Ihle JN, Rice NR: Mol Cell Biol 1987;7: 1304–1309.

    PubMed  CAS  Google Scholar 

  11. Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C: Proc Natl Acad Sci USA 1997;94: 2642–2647.

    Article  PubMed  CAS  Google Scholar 

  12. Kaltschmidt C, Kaltschmidt B, Lannes-Vieira J, Kreutzberg GW, Wekerle H, Baeuerle PA, Gehrmann J: J Neuroimmunol 1994;55: 99–106.

    Article  PubMed  CAS  Google Scholar 

  13. Kaltschmidt C, Kaltschmidt B, Neumann H, Wekerle H, Baueuerle PA: Mol Cell Biol 1994;14: 3981–3992.

    PubMed  CAS  Google Scholar 

  14. Thomas LH, Friedland JS, Sharland M, Becker S: J Immunol 1998;161:1007–1016.

    PubMed  CAS  Google Scholar 

  15. Ting AT, Pimentel-Muinos FX, Seed B: EMBO J 1996;15:6189–6196.

    PubMed  CAS  Google Scholar 

  16. Ishikawa H, Claudio E, Dambach D, Raventos-Suarez C, Ryan C, Bravo R: J Exp Med 1998;187: 985–996.

    Article  PubMed  CAS  Google Scholar 

  17. Liu SF, Ye X, Malik AB: J Immunol 1997;159:3976–3983.

    PubMed  CAS  Google Scholar 

  18. Wingren AG, Parra E, Varga M, Kalland T, Sjogren HO, Hedlund G, Dohlsten M: Crit Rev Immunol 1995;15:235–253.

    PubMed  CAS  Google Scholar 

  19. Liou HC, Jin Z, Tumang J, Andjelic S, Smith KA, Liou ML: Int Immunol 1999;11:361–371.

    Article  PubMed  CAS  Google Scholar 

  20. Gerondakis S, Strasser A, Metcalf D, Grigoriadis G, Scheerlinck JY, Grumont RJ: Proc Natl Acad Sci USA 1996;93:3405–3409.

    Article  PubMed  CAS  Google Scholar 

  21. Tumang JR, Owyang A, Andjelic S, Jin Z, Hardy RR, Liou ML, Liou HC: Eur J Immunol 1998;28: 4299–4312.

    Article  PubMed  CAS  Google Scholar 

  22. Grumont RJ, Rourke IJ, Gerondakis S: Genes Dev 1999;13: 400–411.

    PubMed  CAS  Google Scholar 

  23. Doi TS, Takahashi T, Taguchi O, Azuma T, Obata Y: J Exp Med 1997;185:953–961.

    Article  PubMed  CAS  Google Scholar 

  24. Weih F, Carrasco D, Durham SK, Barton DS, Rizzo CA, Ryseck RP, et al.: Cell 1995;80:331–340.

    Article  PubMed  CAS  Google Scholar 

  25. Caamano JH, Rizzo CA, Durham SK, Barton DS, Raventos-Suarez C, Snapper CM, Bravo R: J Exp Med 1998;187:185–196.

    Article  PubMed  CAS  Google Scholar 

  26. Franzoso G, Carlson L, Poljak L, Shores EW, Epstein S, Leonardi A, et al.: J Exp Med 1998;187: 147–159.

    Article  PubMed  CAS  Google Scholar 

  27. Hilliard B, Xu L, Sun J, Chen Y: FASEB J 2002;16:A243.2.

    Google Scholar 

  28. Hilliard B, Samoilova EB, Liu TT, Rostami AM, Chen Y: J Immunol 1999;163:2937–2943.

    PubMed  CAS  Google Scholar 

  29. Das J, Chen CH, Yang L, Cohn L, Ray P, Ray A: Nature Immunol 2001;2:45–50.

    Article  CAS  Google Scholar 

  30. Ruddle NH: Curr Opin Immunol 1992;4:327–332.

    Article  PubMed  CAS  Google Scholar 

  31. Magnusson C, Vaux DL: Immunol Cell Biol 1999;77:41–46.

    Article  PubMed  CAS  Google Scholar 

  32. Beutler B, Bazzoni F: Blood Cells Mol Dis 1998;24:216–230.

    Article  PubMed  CAS  Google Scholar 

  33. Argiles JM, Lopez-Soriano J, Busquets S, Lopez-Soriano FJ: FASEB J 1997;11:743–751.

    PubMed  CAS  Google Scholar 

  34. Lynch DH, Campbell KA, Miller RE, Badley AD, Paya CV: Behring Inst Mitt 1996:175–184.

  35. Wallach D, Boldin M, Goncharov T, Goltsev Y, Mett I, Malinin N, et al.: Behring Inst Mitt 1996: 144–156.

  36. Baker SJ, Reddy EP: Oncogene 1996:12:1–9.

    PubMed  CAS  Google Scholar 

  37. Mountz JD, Edwards CK 3rd, Cheng J, Yang P, Wang Z, Liu C, Su X, Bluethmann H, Zhou T: Adv Exp Med Biol 1996;406:241–262.

    PubMed  CAS  Google Scholar 

  38. Ware CF, Van Arsdale S, Van Arsdale TL: J Cell Biochem 1996;60: 47–55.

    Article  PubMed  CAS  Google Scholar 

  39. Nagata S, Suda T: Immunol Today 1995;16:39–43.

    Article  PubMed  CAS  Google Scholar 

  40. Stuart PM, Griffith TS, Usui N, Pepose J, Yu X, Ferguson TA: J Clin Invest 1997;99:396–402.

    PubMed  CAS  Google Scholar 

  41. Saas P, Walker PR, Hahne M, Quiquerez AL, Schnuriger V, Perrin G, et al.: J Clin Invest 1997;99: 1173–1178.

    PubMed  CAS  Google Scholar 

  42. French LE, Tschopp J: Behring Inst Mitt 1996;97:156–160.

    PubMed  CAS  Google Scholar 

  43. Malinin NL, Boldin MP, Kovalenko AV, Wallach D: Nature 1997;385:540–544.

    Article  PubMed  CAS  Google Scholar 

  44. Abreu-Martin MT, Vidrich A, Lynch DH, Targan SR: J Immunol 1995;155:4147–4154.

    PubMed  CAS  Google Scholar 

  45. Sneller MC, Wang J, Dale JK, Strober W, Middelton LA, Choi Y, et al.: Blood 1997;89:1341–1348.

    PubMed  CAS  Google Scholar 

  46. Cohen PL, Eisenberg RA: Immunol Today 1992;13:427–428.

    Article  PubMed  CAS  Google Scholar 

  47. Nagata S, Golstein P: Science 1995;267:1449–1456.

    Article  PubMed  CAS  Google Scholar 

  48. Chervonsky AV, Wang Y, Wong FS, Visintin I, Flavell RA, Janeway CA Jr, Matis LA: Cell 1997;89:17–24.

    Article  PubMed  CAS  Google Scholar 

  49. Itoh N, Imagawa A, Hanafusa T, Waguri M, Yamamoto K, Iwahashi H, et al.: J Exp Med 1997;186: 613–618.

    Article  PubMed  CAS  Google Scholar 

  50. Kang SM, Schneider DB, Lin Z, Hanahan D, Dichek DA, Stock PG, Baekkeskov S: Nature Med 1997; 3:738–743.

    Article  PubMed  CAS  Google Scholar 

  51. Giordano C, Stassi G, De Maria R, Todaro M, Richiusa P, Papoff G, et al.: Science 1997;275:960–963.

    PubMed  CAS  Google Scholar 

  52. Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, et al.: Immunity 1995;3:673–682.

    Article  PubMed  CAS  Google Scholar 

  53. Pan G, Ni J, Wei YF, Yu G, Gentz R, Dixit VM: Science 1997;277: 815–818.

    Article  PubMed  CAS  Google Scholar 

  54. Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM: Science 1997;276:111–113.

    Article  PubMed  CAS  Google Scholar 

  55. Pan G, Ni J, Yu G, Wei YF, Dixit VM: FEBS Lett 1998;424:41–45.

    Article  PubMed  CAS  Google Scholar 

  56. Schneider P, Bodmer JL, Thome M, Hofmann K, Holler N, Tschopp J: FEBS Lett 1997;416:329–334.

    Article  PubMed  CAS  Google Scholar 

  57. Meng RD, McDonald ER 3rd, Sheikh MS, Fornace AJ Jr, El-Deiry WS: Mol Ther J Am Soc Gene Ther 2000;1:130–144.

    CAS  Google Scholar 

  58. Sheikh MS, Burns TF, Huang Y, Wu GS, Amundson S, Brooks KS, et al.: Cancer Res 1998;58: 1593–1598.

    PubMed  CAS  Google Scholar 

  59. Sheikh MS, Huang Y, Fernandez-Salas EA, El-Deiry WS, Friess H, Amundson S, et al.: Oncogene 1999;18:4153–4159.

    Article  PubMed  CAS  Google Scholar 

  60. Sheridan JP, Marsters SA, Pitti RM, Gurney A, Skubatch M, Baldwin D, et al.: Science 1997; 277:818–821.

    Article  PubMed  CAS  Google Scholar 

  61. Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N, et al.: EMBO J 1997;16: 5386–5397.

    Article  PubMed  CAS  Google Scholar 

  62. Screaton GR, Mongkolsapaya J, Xu XN, Cowper AE, McMichael AJ, Bell JI: Curr Biol 1997;7: 693–696.

    Article  PubMed  CAS  Google Scholar 

  63. Wu GS, Burns TF, Zhan Y, Alnemri ES, El-Deiry WS: Cancer Res 1999;59:2770–2775.

    PubMed  CAS  Google Scholar 

  64. Sprick MR, Weigand MA, Rieser E, Rauch CT, Juo P, Blenis J, Krammer PH, Walczak H: Immunity 2000;12:599–609.

    Article  PubMed  CAS  Google Scholar 

  65. Bodmer JL, Holler N, Reynard S, Vinciguerra P, Schneider P, Juo P, Blenis J, Tschopp J: Nat Cell Biol 2000;2:241–243.

    Article  PubMed  CAS  Google Scholar 

  66. Zhang XD, Zhang XY, Gray CP, Nguyen T, Hersey P: Cancer Res 2001;61:7339–7348.

    PubMed  CAS  Google Scholar 

  67. Deng Y, Lin Y, Wu X: Genes Dev 2002;16:33–45.

    Article  PubMed  CAS  Google Scholar 

  68. Abulencia JP, Gaspard R, Quackenbush J, konstantopoulos K: FASEB J 2002;16:A656.7.

    Google Scholar 

  69. Mariani SM, Krammer PH: Eur J Immunol 1998;28:1492–1498.

    Article  PubMed  CAS  Google Scholar 

  70. Jeremias I, Herr I, Bochler T, Debatin KM: Eur J Immunol 1998;28:143–152.

    Article  PubMed  CAS  Google Scholar 

  71. Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M, et al.: Nature Med 1999;5:157–163.

    Article  PubMed  CAS  Google Scholar 

  72. Ashkenazi A, Pai RC, Fong S, Leung S, Lawrence DA, Marsters SA, et al.: J Clin Invest 1999;104: 155–162.

    PubMed  CAS  Google Scholar 

  73. Jo M, Kim TH, Seol DW, Esplen JE, Dorko K, Billiar TR, Strom SC Nat Med 2000;6:564–567.

    Article  PubMed  CAS  Google Scholar 

  74. Simon AK, Williams O, Mongkolsapaya J, Jin B, Xu XN, Walczak H, Screaton GR: Proc Natl Acad Sci USA 2001;98:5158–5163.

    Article  PubMed  CAS  Google Scholar 

  75. Martin-Villalba A, Herr I, Jeremias I, Hahne M, Brandt R, Vogel J, et al.: J Neurosci 1999;19: 3809–3817.

    PubMed  CAS  Google Scholar 

  76. Chaudhary PM, Eby M, Jasmin A, Bookwalter A, Murray J, Hood L: Immunity 1997;7:821–830.

    Article  PubMed  CAS  Google Scholar 

  77. Schneider P, Thome M, Burns K, Bodmer JL, Hofmann K, Kataoka T, Holler N, Tschopp J: Immunity 1997;7:831–836.

    Article  PubMed  CAS  Google Scholar 

  78. Hu WH, Johnson H, Shu HB: J Biol Chem 1999;274:30,603–30,610.

    CAS  Google Scholar 

  79. Lin Y, Devin A, Cook A, Keane MM, Kelliber M, Lipkowitz S, Liu ZG: Mol Cell Biol 2000;20:6 6638–6645.

    Article  PubMed  CAS  Google Scholar 

  80. Kumar-Sinha C, Varambally S, Sreekumar A, Chinnaiyan AM: J Biol Chem 2002;277:575–585.

    Article  PubMed  CAS  Google Scholar 

  81. Song K, Chen Y, Goke R, Wilmen A, Seidel C, Goke A, Hilliard B, Chen Y: J Exp Med 2000;191: 1095–1104.

    Article  PubMed  CAS  Google Scholar 

  82. Hilliard B, Wilmen A, Seidel C, Liu TS, Goke R, Chen Y: J Immunol 2001;166:1314–1319.

    PubMed  CAS  Google Scholar 

  83. Goke R, Goke A, Goke B, Chen Y: Cell Immunol 2000;201: 77–82.

    Article  PubMed  CAS  Google Scholar 

  84. Goke R, Goke A, Goke B, El-Deiry WS, Chen Y: Digestion 2001; 64:75–80.

    Article  PubMed  CAS  Google Scholar 

  85. Huguet C, Bouali F, Enrietto PJ, Stehelin D, Vandenbunder B, Abbadie C: Dev Immunol 1998; 5:247–261.

    Article  PubMed  CAS  Google Scholar 

  86. Baldwin AS Jr: Ann Rev Immunol 1996;14:649–683.

    Article  CAS  Google Scholar 

  87. Zhao J, Freeman GJ, Gray GS, Nadler LM, Glimcher LH: J Exp Med 1996;183:777–789.

    Article  PubMed  CAS  Google Scholar 

  88. Pimentel-Muinos FX, Mazana J, Fresno M: Eur J Immunol 1995; 25:179–186.

    Article  PubMed  CAS  Google Scholar 

  89. Rensing-Ehl A, Hess S, Ziegler-Heitbrock HW, Riethmuller G, Engelmann H: J Inflamm 1995;45: 161–174.

    PubMed  CAS  Google Scholar 

  90. Los M, Schenk H, Hexel K, Baeuerle PA, Droge W, Schulze-Osthoff K: EMBO J 1995;14: 3731–3740.

    PubMed  CAS  Google Scholar 

  91. Munoz C, Pascual-Salcedo D, Castellanos MC, Alfranca A, Aragones J, Vara A, et al.: Blood 1996;88:3482–3490.

    PubMed  CAS  Google Scholar 

  92. O'Neill LA, Kaltschmidt C: Trends Neurosce 1997;20:252–258.

    Article  Google Scholar 

  93. Stricker K, Serfling E, Krammer PH, Falk W: Eur J Immunol 1993; 23:1475–1480.

    Article  PubMed  CAS  Google Scholar 

  94. Arsura M, FitzGerald MJ, Fausto N, Sonenshein GE: Cell Growth Differ 1997;8:1049–1059.

    PubMed  CAS  Google Scholar 

  95. Van Antwerp DJ, Martin SJ, Kafri T, Green DR, Verma IM: Science 1996;274:787–789.

    Article  PubMed  Google Scholar 

  96. Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS Jr: Science 1998;281:1680–1683.

    Article  PubMed  CAS  Google Scholar 

  97. Mayo MW, Wang CY, Cogswell PC, Rogers-Graham KS, Lowe SW, Der CJ, Baldwin AS Jr: Science 1997;278:1812–1815.

    Article  PubMed  CAS  Google Scholar 

  98. Wang CY, Mayo MW, Baldwin AS Jr: Science 1996;274: 784–787.

    Article  PubMed  CAS  Google Scholar 

  99. Wu M, Lee H, Bellas RE, Schauer SL, Arsura M, Katz D, et al.: EMBO J 1996;15:4682–4690.

    PubMed  CAS  Google Scholar 

  100. Liu ZG, Hsu H, Goeddel DV, Karin M: Cell 1996;87:565–576.

    Article  PubMed  CAS  Google Scholar 

  101. Wu MX, Ao Z, Prasad KV, Wu R, Schlossman SF: Science 1998; 281:998–1001.

    Article  PubMed  CAS  Google Scholar 

  102. Liu W, Ichikawa K, Zhang H, Zhao L, Ohtsuka T, Wang Z, et al.: FASEB J 2002;16:A759.24.

    Article  Google Scholar 

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  1. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 421 Curie Blvd, 19104, Philadelphia, PA

    Youhai H. Chen

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Chen, Y.H. Genes and genomics of autoimmune inflammation. Immunol Res 27, 169–178 (2003). https://doi.org/10.1385/IR:27:2-3:169

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