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Cardiac valvulopathy in the antiphospholipid syndrome

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Abstract

The Libman and Sacks non bacterial endocarditis was reported in 1924 in patients with SLE. Its relation to the anti cardiolpin syndrome has only been described as recently as the last decade. In this paper we review the deposition of theses antibodies on the valve with complement components initiating the deformation of the valve. The valvulopathy in APS is quite common and may lead to valve replacement. In addition, a diversity of manifestations are detailed. More awareness should be drawn to this new complication of APS.

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References

  1. Hughes, G. R. V., Harris, E. N., and Gharavi, A. E. (1986), J. Rheumatol. 13, 486–489.

    PubMed  CAS  Google Scholar 

  2. Harris, E. N. (1990), J. Rheumatol. 17, 733–735.

    PubMed  CAS  Google Scholar 

  3. Asherson, R. A., and Cervera, R. (1994), Lupus 3, 293–298.

    PubMed  CAS  Google Scholar 

  4. Briley, D. P., Coull, B. M., and Goodnight, S. H. (1989), Ann. Neurol. 25, 221–227.

    Article  PubMed  CAS  Google Scholar 

  5. Levine, S. R., Deegan, M. J., Futrell, N., and Welch, K. M. A. (1990), Neurology 40, 1181–1189.

    PubMed  CAS  Google Scholar 

  6. Rote, N. S. (1990), J. Clin. Immunoassay 13, 34–42.

    Google Scholar 

  7. Grob, J. J. and Bonerandi, J. J. (1989), J. Am. Acad. Dermatol. 20, 1063–1069.

    PubMed  CAS  Google Scholar 

  8. Asherson, R. A. and Hughes, G. R. V. (1989), Clin. Exp. Rheumatol. 7, 225–228.

    PubMed  CAS  Google Scholar 

  9. Libman, E. and Sacks, B. (1924), Arch. Intern. Med. 33, 701–737.

    Google Scholar 

  10. Bridgen, W., Bywaters, E. G., Lessof, M. H., and Ross, I. P. (1960), Br. Heart J. 22, 1–16.

    Google Scholar 

  11. Kong, T. Q., Kellum, R. F., and Haserick, J. R. (1962), Circulation 26, 7–11.

    PubMed  CAS  Google Scholar 

  12. Klinkhoff, A. V., Thompson, C. R., Reid, G. D., and Tomlinson, C. W. (1985), JAMA 253, 3273–3277.

    Article  PubMed  CAS  Google Scholar 

  13. Galve, E., Candell-Riera, J., Pigrau, C., Permanyer-Miralda, G., Garcia-Del-Castillo, H., and Soler-Soler, J., (1988), N. Engl. J. Med. 319, 817–823.

    Article  PubMed  CAS  Google Scholar 

  14. Straaton, K. V., Chatham, W. W., Reveille, J. D., Koopman, W. J., and Smith, S. H. (1988), Am. J. Med. 85, 645–650.

    Article  PubMed  CAS  Google Scholar 

  15. Chartash, E. K., Lans, D. M., Paget, S. A., Qamar, T., and Lockshin, M. D. (1989), Am. J. Med. 86, 407–412.

    Article  PubMed  CAS  Google Scholar 

  16. Khamashta, M. A., Gil, A., Asherson, R. A., Vazquez, J. J., and Hughes, G. R. V. (1989), Am. J. Med. 86, 633–634 (Letter).

    Article  PubMed  CAS  Google Scholar 

  17. Straaton, K. V., Chatham, W. W., Smith, S. H., and Koopman, W. J. (1989), N. Engl. J. Med. 320, 740 (Letter).

    Google Scholar 

  18. Galve, E., Ordi, J., Candell-Riera, J., Permanyer-Miralda, G., Vilardell, M., and Soler-Soler, J. (1989), N. Engl. J. Med. 320, 740–741 (Letter).

    Google Scholar 

  19. Nihoyannopoulos, P., Gomez, P. M., Joshi, J., Loizou, S., Walport, M. J., and Oakley, C. M. (1990), Circulation 82, 369–375.

    PubMed  CAS  Google Scholar 

  20. Khamashta, M. A., Cervera, R., Asherson, R. A., Font, J., Gil, A., Coltart, D. J., et al. (1990), Lancet 335, 1541–1544.

    Article  PubMed  CAS  Google Scholar 

  21. Hughes, G. R. V. (1993), Lancet 342, 341–344.

    Article  PubMed  CAS  Google Scholar 

  22. Triplett, D. A. (1994), Lupus 3, 281–287.

    PubMed  CAS  Google Scholar 

  23. Cervera, R. (2000), J. Autoimmun. 2, 123–125.

    Article  Google Scholar 

  24. Vianna, J. L., Khamashta, M. A., Ordi-Ros, J., Font, J., Cervera, R., Lopez-Soto, A., et al. (1994), Am. J. Med. 96, 3–9.

    Article  PubMed  CAS  Google Scholar 

  25. Khamashta, M. A., Cervera, R., Asherson, R. A., Font, J., Gil, A., Coltart, D. J., et al. (1990), Lancet 335, 1541–1544.

    Article  PubMed  CAS  Google Scholar 

  26. Leung, W. H., Wong, K. L., Lau, C. P., Wong, C. K., and Liu, H. W. (1990), Am. J. Med. 89, 411–419.

    Article  PubMed  CAS  Google Scholar 

  27. Cervera, R., Khamashta, A., Font, J., Reyes, P. A., Vianna, J. L., Lopez-Soto, A., et al. (1991), Lupus 1, 43–47.

    PubMed  CAS  Google Scholar 

  28. Galve, E., Ordi, J., Barquinero, J., Evangelista, A., Vilardell, M., Soler-Soler, J. (1992), Annu. Intern. Med. 116, 293–298.

    CAS  Google Scholar 

  29. Mandell, B. F. (1987), Semin. Arthritis Rheum. 17, 126–141.

    Article  PubMed  CAS  Google Scholar 

  30. Bulkley, B. H. and Roberts, W. C. (1975), Am. J. Med. 58, 243–264.

    Article  PubMed  CAS  Google Scholar 

  31. Nickele, G. A., Foster, P. A., and Kenny, D. (1994), Am. Heart. J. 128, 1245–1247.

    Article  PubMed  CAS  Google Scholar 

  32. Galve, E., Ordi, J., Barquinero, J., Evangelista, A., Vilardell, M., and Soler-Soler, J. (1992), Ann. Intern. Med. 116, 293–298.

    PubMed  CAS  Google Scholar 

  33. Roldan, C. A., Shively, B. K., Lau, C. C., Gurule, F. T., Smith, E. A., and Crawford, M. H. (1992), J. Am. Coll. Cardiol. 20, 1127–1134.

    Article  PubMed  CAS  Google Scholar 

  34. Gleason, C. B., Stoddard, M. F., Wagner, S. G., Longaker, R. A., Pierangeli, S., and Harris, E. N. (1993), Am. Heart J. 125, 1123–1129.

    Article  PubMed  CAS  Google Scholar 

  35. Espinola-Zavaleta, N., Amigo, M. C., Vargas-Barron, J., Cardenas Romero, A., Vidal, M., and Roldan, J. (2001), Lupus 10, 511–513.

    Article  PubMed  CAS  Google Scholar 

  36. Nesher, G., Ilani, J., Rosenmann, D., and Abraham, A. S. (1997), Semin. Arthritis Rheum. 27, 27–35.

    Article  PubMed  CAS  Google Scholar 

  37. The Antiphospholipid antibodies in Stroke Study Group. (1990), Stroke 21, 1268–1273.

    Google Scholar 

  38. Lehman, T. J. A., Palmeri, S. T., Hastings, C., Klippel, J. H., and Plotz, P. H. (1983), J. Rheumatol. 10, 655–658.

    PubMed  CAS  Google Scholar 

  39. Ziporen, L., Goldberg, I., Arad, M., Hojnik, M., Ordi-Ros, J., Afek, A., et al. (1996), Lupus 5, 196–205.

    PubMed  CAS  Google Scholar 

  40. Amital, H., Langevitz, P., Levy, Y., Afek, A., Goldberg, I., Pras, M., et al. (1999), Clin. Exp. Rheumatol. 17, 99–102.

    PubMed  CAS  Google Scholar 

  41. Hasselaar, P., Derksen, R. H. W. M., Blokzijl, L., and de Groot, P. G. (1990), Thromb. Haemost. 63, 169–173.

    PubMed  CAS  Google Scholar 

  42. Del Papa, N., Guidali, L., Spatola, L., Bonara, P., Borghi, M. O., Tincani, A., et al. (1995), Clin. Exp. Rheumatol. 13, 179–185.

    PubMed  Google Scholar 

  43. Kornberg, A., Blank, M., Kaufman, S., and Shoenfeld, Y. (1994), J. Immunol. 153, 1328–1332.

    PubMed  CAS  Google Scholar 

  44. Galli, M. and Bevers, E. M. (1994), Lupus 3, 223–228.

    PubMed  CAS  Google Scholar 

  45. Farsi, A., Domeneghetti, M. P., Fedi, S., Capanni, M., Giusti, B., Marcucci, R., et al. (1999), Autoimmunity 30, 93–98.

    Article  PubMed  CAS  Google Scholar 

  46. Hojnik, M., George, J., Ziporen, L., and Shoenfeld, Y. (1996), Circulation 93, 1579–1587.

    PubMed  CAS  Google Scholar 

  47. Cervera, R., Font, J., Pare, C., Azqueta, M., Perez-Villa, F., Lopez-Soto, A., and Ingelmo, M. (1992), Ann. Rheum. Dis. 51, 156–159.

    Article  PubMed  CAS  Google Scholar 

  48. Jouhikainen, T., Pohjola-Sintonen, S., and Stephansson, E. (1994), Lupus 3, 167–172.

    PubMed  CAS  Google Scholar 

  49. Gleason, C. B., Stoddard, M. F., Wagner, S. G., Longaker, R. A., Pierangeli, S., and Harris, E. N. (1993), Am. Heart J. 125, 1123–1129.

    Article  PubMed  CAS  Google Scholar 

  50. Vianna, J. L., Khamashta, M. A., Ordi-Ros, J., Font, J., Cervera, R., Lopez-Soto, A., et al. (1994), Am. J. Med. 96, 3–9.

    Article  PubMed  CAS  Google Scholar 

  51. Afek, A., Shoenfeld, Y., Manor, R., Goldberg, I., Ziporen, L., George, J., et al. (1999), Lupus 8, 502–507.

    Article  PubMed  CAS  Google Scholar 

  52. Espinola-Zavaleta, N., Vargas-Barron, J., Colmenares-Galvis, T., Cruz-Cruz, F., Romero-Cardenas, A., Keirns, C., and Amigo, M. C. (1999), Am. Heart J. 137, 973–978.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine “B” Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, 52621, Tel-Hashomer, Israel

    Shaul Lev & Yehuda Shoenfeld

  2. Research Center of Autoimmune Diseases, Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Hashomer, Israel

    Shaul Lev & Yehuda Shoenfeld

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  1. Shaul Lev
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  2. Yehuda Shoenfeld
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Correspondence to Yehuda Shoenfeld.

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Lev, S., Shoenfeld, Y. Cardiac valvulopathy in the antiphospholipid syndrome. Clinic Rev Allerg Immunol 23, 341–348 (2002). https://doi.org/10.1385/CRIAI:23:3:341

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