Abstract
To examine whether an accumulation of Ca in the tissues was accompanied by an increase of Mg, the authros investigated the relationships between Ca and Mg contents in the common iliac arteries, aortic valves, xiphoid processes, costal cartilages, posterior longitudinal ligaments, trigeminal nerves, and ribs by inductively coupled plasma-atomic emission spectrometry. After the ordinary dissections by medical students were finished, the common iliac arteries, aortic valves, xiphoid processes, bilateral the fourth costal cartilages, posterior longitudinal ligaments between the fourth and fifth cervical vertebrae, trigeminal nerves, and bilateral the sixth ribs were resected from the subjects and elements were determined. It was found that there were extremely significant direct correlations between Ca and Mg contents in all of the common iliac arteries, aortic valves, costal cartilages, posterior longitudinal ligaments, and trigeminal nerves, whereas there were significant direct correlations in both the xiphoid processes and ribs. As for the tissues containing Ca higher than 20 mg/g, the average mass ratios of Mg/Ca were similar among the seven tissues. As Ca increased in all of the common iliac arteries, aortic valves, xiphoid processes, costal cartilages, posterior longitudinal ligaments, trigeminal nerves, and ribs, Mg increased simultaneously in the seven tissues.
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S. Y. Yu and H. T. Blumenthal, The calcification of elastic fibers. I. Biochemical studies, J. Gerontol. 18, 119–126 (1963).
S. Tohno and Y. Tohno, Age-related differences in calcium accumulation in human arteries. Cell. Mol. Biol. 44, 1252–1263 (1998).
Y. Tohno, S. Tohno, Y. Moriwake, et al., Accumulation of calcium and phosphorus accompanied by increase of magnesium and decrease of sulfur in human arteries, Biol. Trace Element Res. 82, 9–19 (2001).
Y. Tohno, S. Tohno, Y. Moriwake, et al., Simultaneous accumulation of calcium, phosphorus, and magnesium in various human arteries, Biol. Trace Element Res. 82, 21–28 (2001).
S. Tohno, Y. Tohno, Y. Moriwake, et al., Quantitative changes of calcium, phosphorus, and magnesium in common iliac arteries with aging, Biol. Trace Element Res. 84, 57–66 (2001).
S. Tohno, Y. Tohno, T. Minami, et al., Elements of calcified sites in human thoracic aorta, Biol. Trace Element Res. 86, 23–30 (2002).
Y. Tohno, S. Tohno, P. Mahakkanukrauh, et al., Mass ratios of magnesium to calcium and phosphorus in the arteries of Japanese and Thai, Biol. Trace Element Res. 91, 217–230 (2003).
Y. Tohno, S. Tohno, T. Minami, et al., Differences in accumulation of elements in human cardiac valves. Biol. Trace Element Res. 77, 107–118 (2000).
S. Tohno, Y. Tohno, Y. Moriwake, et al., Compositional changes of the aortic valve similar to the artery with aging. Biol. Trace Element Res. 87, 83–93 (2002).
K. Furuta, Y. Tohno, S. Tohno, et al., Compositional changes of the xiphoid process and costal cartilage with aging. Biol. Trace Element Res. 95, 123–137 (2003).
M. Utsumi, C. Azuma, S. Tohno, et al., Increases of calcium and magnesium and decrease of iron in human posterior longitudinal ligament of the cervical spine with aging, Biol. Trace Element Res., in press.
M. Utsumi, S. Tohno, Y. Tohno, et al., Age-related changes of elements with their relationships in human cranial and spinal nerves. Biol. Trace Element Res., in press.
Y. Tohno, S. Tohno, H. Matsumoto, et al., A trial of introducing soft X-ray apparatus into dissection practice for students, J. Nara Med. Assoc. 36, 365–370 (1985) (in Japanese).
A. Bigi, E. Foresti, A. Incerti, et al., Structural and chemical characterization of the inorganic deposits in calcified human aortic wall, Inorgan. Chim. Acta 55, 81–85 (1980).
M. Hayashi, T. Osakabe, F. Ushio, et al., Qualitative change in the elastin from the calcified portion of human artery, Jpn. J. Geriat. 36, 404–407 (1999) (in Japanese).
C. Nystrom-Rosander, U. Lindh, N. G. Ilback, et al., Interactions between Chlamydia pneumoniae and trace elements: a possible link to aortic valve sclerosis. Biol. Trace Element Res. 91, 97–110 (2003).
S. Tohno, Y. Tohno, Y. Moriwake, et al., Relationships among element contents in the internal jugular vein similar to the arteries, Biol. Trace Element Res. 88, 223–233 (2002).
Y. Tohno, S. Tohno, C. Azuma, et al., Age-related changes of elements in human thoracic ducts and azygos veins and relationships among elements, Biol. Trace Element Res. 96, 93–107 (2003).
Y. Tohno, S. Tohno, H. Satoh, et al., Compositional changes of human mitral valves with aging, Biol. Trace Element Res. 88, 203–213 (2002).
M. Yamada, Y. Tohno, S. Tohno, et al., Age-related changes of elements and relationships among elements in human tendons and ligaments, Biol. Trace Element Res. 98, 129–142 (2004).
Y. Tohno, S. Tohno, M.-o. Yamada, et al., Age-related changes of elements and relationships among elements in the common bile and pancreatic ducts, Biol. Trace Element Res., in press.
M. Yamada, Y. Tohno, Y. Takakura, et al., Age-related changes of element contents in human tendon of the iliopsoas muscle and the relationships among elements, Biol. Trace Element Res. 91, 57–66 (2003).
R. Z. Le Geros, S. R. Contiguglia, and A. C. Alfrey, Pathological calcification associated with uremia, two types of calcium phosphate deposits, Calcif. Tissue Res. 13, 173–185 (1973).
N. C. Blumenthal, F. Betts, and A. S. Posner, Stabilization of amorphous calcium phosphate by Mg and ATP, Calcif. Tissue Res. 23, 245–250 (1977).
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Tohno, Y., Tohno, S., Azuma, C. et al. Accumulation of calcium in human common iliac artery, aortic valve, xiphoid process, costal cartilage, posterior longitudinal ligament, trigeminal nerve, and rib accompanied by increase of magnesium. Biol Trace Elem Res 102, 83–90 (2004). https://doi.org/10.1385/BTER:102:1-3:083
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DOI: https://doi.org/10.1385/BTER:102:1-3:083