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Effect of bis(acetato)tetrakis(imidazole) copper(II) in delaying the onset and reducing the mortality rate of strychnine- and thiosemicarbazide—Induced convulsions

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Abstract

The anticonvulsant activity of bis(acetato)tetrakis(imidazole) copper(II), Cu(OAc)2(Im)4, was studied in normal mice using chemical convulsions induced by strychnine, thiosemicarbazide, picrotoxin, and pentelenetetrazol. Intraperitoneal administration of Cu(OAc) 2(Im)4, 50 mg/kg body mass, has delayed the onset of strychnine (3 mg/kg)-induced convulsion by 204% (p≤0.005) and thiosemicarbazide (20 mg/kg)-induced convulsant by 61% (p≤0.005). The changes in the onset of picrotoxin-(6 mg/kg) and pentelenetetrazol (50 mg/kg)-induced convulsions were not significant. The same dosage of the copper compound was effective in delaying the lethal time and reducing the mortality rate of treated animals. The anticonvulsant activity of Cu(OAc) 2(Im)4 complex against strychnine was not related to its constituents because the inorganic form of copper such as copper chloride, copper acetate, and the parent imidazole has no anticonvulsant activity. Other copper(II) complexes like copper(II)aspirinate and bis(acetato)bis(2-methyl imidazole) copper(II) were less effective.

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References

  1. J. R. Prohaska, Biochemical functions of copper in animals, in Essential and Toxic Trace Elements in Human Health and Disease, A. S. Prasad, ed., Liss, New York, pp. 105–124 (1988).

    Google Scholar 

  2. J. R. J. Sorenson, Copper complexes offer a physiological approach to treatment of chronic diseases, Prog. Med. Chem. 26, 437–568 (1989).

    Article  PubMed  CAS  Google Scholar 

  3. E. I. Solomon, U. M. Sundaram, and T. E. Machonkin, Multicopper oxidases and oxygenases, Chem. Rev. 96, 2563–2605 (1996).

    Article  PubMed  CAS  Google Scholar 

  4. L. W. Oberley, S. W. Leuthauser, R. F. Pasternack, T. D. Obeley, L. Schutt, and J. R. J. Sorenson, Anticancer activity of metal compounds with superoxide dismutaze activity, Agents Actions 15, 535–538 (1984).

    Article  PubMed  CAS  Google Scholar 

  5. J. R. J. Sorenson, Copper chelates as possible active forms of antiarthritic agents, J. Med. Chem. 19, 135–148 (1976).

    Article  PubMed  CAS  Google Scholar 

  6. D. H. Brown, W. E. Smith, and J. W. Teape, Anti-inflammatory effects of some copper complexes, J. Med. Chem. 23, 729–734 (1980).

    Article  PubMed  CAS  Google Scholar 

  7. J. R. J. Sorenson, L. W. Oberley, and V. Kishore, Copper complexes: a physiological approach to the treatment of inflammatory diseases, Inorg. Chim. Acta 91, 285–294 (1984).

    Article  CAS  Google Scholar 

  8. S. Okuyama, S. Hashimoto, H. Aihara, W. M. Willingham, and J. R. J. Sorenson. Copper complexes of non-steroidal anti-inflammatory agents: analgesic activity and possible opioid receptor activation, Agents Actions 21, 130–144 (1989).

    Article  Google Scholar 

  9. J. R. J. Sorenson, K. Ramakrishna, and T. M. Rolniak, Antiulcer activities of d-penicillamine copper complexes, Agents Actions 12(3), 408–411 (1982).

    Article  PubMed  CAS  Google Scholar 

  10. J. R. J. Sorenson, L. W. Oberley, R. K. Crouch, et al., Pharmacologic activities of copper compounds in chronic diseases, Biol. Trace Element Res. 5, 257–274 (1983).

    CAS  Google Scholar 

  11. A. Agrawal, N. Singh, R. Agrawal, A. Sedhi, and P. Tandon, Synthesis, structure, and antitumor activity of N-salicylcyl-N-(2-furyl thiocarbonyl) hydrazine and its copper(II) complex, J. Med. Chem. 29, 199 (1986).

    Article  PubMed  CAS  Google Scholar 

  12. S. E. Gandy, M. G. Buse, J. R. J. Sorenson, and R. K. Crouch, Attenuation of streptozotocin diabetes with superoxide dismutase like copper(II) (3,5-diisopropyl-salicylate)2 in the rat, Diabetologia 24(6), 437–440 (1993).

    Google Scholar 

  13. A-S. Abdul-Ghani, A. L. AbuHijleh, N. Nahas, and R. Amin, Hypoglycemic effect of copper(II) acetate imidazole complexes. Biol. Trace Element Res. 54, 143–151 (1996).

    CAS  Google Scholar 

  14. J. R. J. Sorenson Cu, Fe, Mn, and Zn chelates offer a medicinal chemistry approach to overcoming radiation injury, Curr. Med. Chem. 9, 639–662 (2002).

    PubMed  CAS  Google Scholar 

  15. J. R. J. Sorenson, L. S. F. Soderberg, L. W. Chang, et al., Copper-, iron-, manganese- and zinc-3,5-diisopropylsalicylate complexes increase survival of gamma-irradiated mice, Eur. J. Med. Chem. 28, 221–229 (1993).

    Article  CAS  Google Scholar 

  16. D. Suriyachan, S. Patarakitvanit, and P. Ratananakorn, R. Thai Army Med. J. 42, 145–148 (1989).

    Google Scholar 

  17. J. R. J. Sorenson, Copper chelates as possible active metabolites of the antiarthritic and antiepileptic drugs, J. Appl. Nutr. 32, 4–9 (1980).

    CAS  Google Scholar 

  18. G. Alznet, S. Ferrer, J. Borras, and J. R. J. Sorenson. Anticonvulsant properties of copper acetazoleamide complexes, J. Inorg. Biochem. 55(2), 147–151 (1994).

    Article  Google Scholar 

  19. P. Y. Boukan, E. A. Busnot, F. Busnot, A. Laclaire, and T. A. Bernard, Structure du di-μ-acetato-bis[acetato bis(methyl-1 imidazol) cuivre(II)]hexahydrate, Acta Crystall. B38, 2458–2461 (1982).

    Google Scholar 

  20. P. Lemoine, B. Viossat, G. Morgant, et al., Synthesis, crystal structure, EPR properties and anticonvulsant activities of binuclear and mononuclear 1,10-phenanthroline and salicylate ternary copper (II) complexes J. Inorg. Biochem. 89, 18–28 (2002).

    Article  PubMed  CAS  Google Scholar 

  21. K. Wada, Y. Fujibayashi, and A. Yokoyama, Copper(II) 2,3-butanedionebis(N4-methylthiosemicarbazone) stable superoxide dismutase-like copper complex with high membrane penetrability, Arch Biochem. Biophys. 310, 1–5 (1994).

    Article  PubMed  CAS  Google Scholar 

  22. N. Horn, K. Heydorn, E. Damsgaard, I. Tygstrup and S. Vestermark, Is Menkes syndrome a copper storage disorder? Clin. Gen. 14, 186–187 (1978).

    Article  CAS  Google Scholar 

  23. S. Greenfield, W. T. Norton, and P. Morell, Quaking mouse: isolation and characterization of mylein protein, J. Neurochem. 18, 2119–2128 (1971).

    Article  PubMed  CAS  Google Scholar 

  24. D. M. Hunt, Primary defect in copper transport underlies mottled mutants in the mouse, Nature 249, 852–854 (1974).

    Article  PubMed  CAS  Google Scholar 

  25. T. R. Price and P. M. Silberfarb, Convulsions following disulfiram treatment, Am. J. Psychol. 133, 235 (1976) (letter).

    CAS  Google Scholar 

  26. A. L. AbuHijleh, C. Wood, and I. Y. Ahmed, Synthesis and molecular structure of monomeric copper(II) acetate with 2-methylimidazole and 1,2-dimethylimidazole, Inorg. Chim. Acta 190, 11–17 (1991).

    Article  CAS  Google Scholar 

  27. A. L. Abu-Hijleh and C. Woods, Synthesis, spectroscopic and structural characterization of bis(acetato) tetrakis(imidazole) copper(II): a model complex of DNA binding, Inorg. Chim. Acta 194, 9–14 (1992).

    Article  CAS  Google Scholar 

  28. R. L. Krall, J. K. Penry, B. G. White, H. J. Kupferburg, and E. A. Swinyard, Antiepileptic drug development. II Anticonvulsant drug screening, Epilepsia 19, 409–428 (1978).

    PubMed  CAS  Google Scholar 

  29. B. S. Meldrum, Epilepsy, in Molecular Basis of Neuropathology, A. N. Davison and R. H. Thompson, eds., Edward Arnold, London, pp. 265–301 (1981).

    Google Scholar 

  30. W. Loscher, and H. H. Frey, Effect of convulsant and anticonvulsant agents on level and metabolism of GABA in mouse brain, Naunyn-Schmiedebergs Arch. Pharmacol. 296, 263–269 (1977).

    Article  PubMed  CAS  Google Scholar 

  31. Y. Yashino and K. A. C. Elliot, Effect of various conditions on the movement of carbon atoms derived from glucose into and out of proteins in rat brain, Can. J. Biochem. 48, 236–243 (1970).

    Article  Google Scholar 

  32. B. L. Booth, E. Pitters, B. Mayer, and J. R. J. Sorenson, Down regulation of porcine heart diaphorase reactivity by trimanganese hexakis (3,5-diisopropyl salicylate) Mn 3(3,5-DIPS)6, and down regulation of nitric oxide synthase reactivity by Mn 3(3,5-DIPS)6 and Cu(II)2(3,5-DIPS)4, Metal-Based Drugs 6, 111–120 (1999).

    Article  CAS  PubMed  Google Scholar 

  33. G. Morgant, N.-H. Dung, J.-C. Daran, et al., Low-temperature crystal structures of tetrakis-μ-3,5-diisopropylsalicylatobis-dimethyl formamido dicopper (II) and tetrakis-μ-3,5-diisopropylsalicylatobis-diethyletheratodicopper(II) and their role in modulating polymorphonuclear leukocyte activity in overcoming seizures, J. Inorg. Biochem. 81, 11–22 (2000).

    Article  PubMed  CAS  Google Scholar 

  34. B. Viossat, J.-C. Duran, G. Savouret, et al., Low temperature (180 K) crystal structure, electron paramagnetic resonance spectroscopy, and propitious anticonvulsant activities of Cu(II)2(aspirinate)4(DMF)2 and other Cu(II)2(aspirinate)4 chelates, J. Inorg. Biochem. 96, 375–385 (2003).

    Article  PubMed  CAS  Google Scholar 

  35. M. S. Horning and P. Q. Trombley, Zinc and copper influence excitability of rat olfactory bulb neurons by multiple mechanisms, J. Neurophysiol. 86, 1652–1660 (2001).

    PubMed  CAS  Google Scholar 

  36. J. R. J. Sorenson, D. O. Rauls, K. Ramakrishna, R. E. Stull, and A. N. Voldeng, in Trace Substances in Environmental Health-III. Anticonvulsant Activity of Some Copper Complexes, D. D. Hemphill, ed. University of Missouri Press, Columbia, MO, pp. 360–367 (1979).

    Google Scholar 

  37. H. H. A. Dollwet, J. B. McNicholas, A. Pezesk, and J. R. J. Sorenson, Superoxide dismutase-mimetic activity of antiepileptic drug copper complexes, Trace Elements Med. 4, 13–20 (1987).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Physiology Department, Faculty of Medicine, Al-Quds University, P. O. Box 19356, Jerusalem West Bank, Palestine

    Abdul-Salam Abdul-Ghani

  2. Department of Chemistry, Birzeit University, P. O. Box 14, Birzeit, West Bank, Palestine

    A. Latif Abu-Hijleh

  3. Department of Biology and Biochemistry, Faculty of Science, Birzeit University, P. O. Box 14, Birzeit, West Bank, Palestine

    Munir Qazzaz

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  1. Abdul-Salam Abdul-Ghani
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  2. A. Latif Abu-Hijleh
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  3. Munir Qazzaz
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Abdul-Ghani, AS., Abu-Hijleh, A.L. & Qazzaz, M. Effect of bis(acetato)tetrakis(imidazole) copper(II) in delaying the onset and reducing the mortality rate of strychnine- and thiosemicarbazide—Induced convulsions. Biol Trace Elem Res 101, 87–95 (2004). https://doi.org/10.1385/BTER:101:1:87

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  • DOI: https://doi.org/10.1385/BTER:101:1:87

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