Abstract
The number of published studies on transduction of tumor cells in vivo using recombinant adeno-associated virus (rAAV) vectors is very limited compared with those that have been published on targeting normal cells. A major reason for this can be attributed to the biology of the vector itself. AAV, being a nonpathogenic vector capable of providing transgene integration and long-term expression, is ideally suited for the correction of metabolic defects either to replace a defective protein/enzyme or to elevate their otherwise suboptimal levels in the system. However, increased understanding of both the biology of tumor progression and potential utility of AAV-based vectors suggests that this vector can also be wisely used for cancer gene therapy.
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© 2004 Humana Press Inc.,Totowa, NJ
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Ponnazhagan, S., Hoover, F. (2004). Delivery of DNA to Tumor Cells In Vivo Using Adeno-Associated Virus. In: Heiser, W.C. (eds) Gene Delivery to Mammalian Cells. Methods in Molecular Biology™, vol 246. Humana Press. https://doi.org/10.1385/1-59259-650-9:237
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DOI: https://doi.org/10.1385/1-59259-650-9:237
Publisher Name: Humana Press
Print ISBN: 978-1-58829-095-3
Online ISBN: 978-1-59259-650-8
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