Abstract
Investigations designed to unravel the role of protein kinase C (PKC) isoforms in the regulation of various intracellular signaling events have been traditionally based on a linear paradigm. Activation of a given molecule (such as a PKC isoform) is modeled to sequentially activate or inhibit another kinase, which in turn affects the activity state of another “downstream” element, and the summation of many protein kinases in series constitutes a signaling pathway. This linear paradigm has served as a valuable framework for the investigation of one or a few target kinases within a particular PKC signaling pathway for several decades.
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Pass, J.M., Zhang, J., Vondriska, T.M., Ping, P. (2003). Functional Proteomic Analysis of the Protein Kinase C Signaling System. In: Newton, A.C. (eds) Protein Kinase C Protocols. Methods in Molecular Biology™, vol 233. Humana Press. https://doi.org/10.1385/1-59259-397-6:369
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DOI: https://doi.org/10.1385/1-59259-397-6:369
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