Abstract
The seminal discovery of protein kinase C (PKC) by Nishizuka and co-workers (1) in the late 1970s provided the first chapter in the story of one of the most studied enzymes in biology. The subsequent finding that PKC transduces signals that cause lipid hydrolysis, followed shortly thereafter by the discovery that PKC was the long sought-after receptor for the potent tumor-promoting phorbol esters, catapulted PKC to the forefront of research on signal transduction. More than 35,000 research articles have been published on PKC. An abundance of reviews describe the structure, regulation, and biological function of PKC and the interested reader is referred to these for a more detailed overview than the brief one provided below (1–11). The goal of this volume is to present a lab manual on classic and novel techniques that are currently used for studying PKC.
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References
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© 2003 Humana Press Inc., Totowa, NJ
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Newton, A.C. (2003). The Ins and Outs of Protein Kinase C. In: Newton, A.C. (eds) Protein Kinase C Protocols. Methods in Molecular Biology™, vol 233. Humana Press. https://doi.org/10.1385/1-59259-397-6:3
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DOI: https://doi.org/10.1385/1-59259-397-6:3
Publisher Name: Humana Press
Print ISBN: 978-1-58829-068-7
Online ISBN: 978-1-59259-397-2
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