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Biochemical Endophenotypes in Personality Disorders

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Psychiatric Genetics

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 77))

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Abstract

Candidate gene association studies in psychiatric disorders have suffered from difficulties in replication. One strategy for overcoming this difficulty is a focus on endophenotypes. If most psychiatric disorders are polygenic and are caused by numerous genes—each contributing a small effect and conferring susceptibility to the phenotype, then it is difficult to identify the influence of each of these genetic contributions to the phenotype. A recent approach, which is the focus of this volume, is the identification of endophenotypes—components of a syndrome that may be influenced by a smaller number of genes and may be more easily associated with a genotype. Other chapters (7,9,10) cover cognitive, electrophysiologic, and neuroimaging endophenotypes. This chapter reviews promising biochemical endophenotypes, using personality disorders as a model.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA

    Antonia S. New

  2. Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA

    Larry J. Siever

Authors
  1. Antonia S. New
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  2. Larry J. Siever
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Editor information

Editors and Affiliations

  1. Hôpital Albert Chenevier, Creteil, France

    Marion Leboyer MD, PhD

  2. Hôpital Henri Mondor, Creteil, France

    Frank Bellivier MD, PhD

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© 2003 Humana Press Inc.

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New, A.S., Siever, L.J. (2003). Biochemical Endophenotypes in Personality Disorders. In: Leboyer, M., Bellivier, F. (eds) Psychiatric Genetics. Methods in Molecular Medicine™, vol 77. Humana Press. https://doi.org/10.1385/1-59259-348-8:199

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  • DOI: https://doi.org/10.1385/1-59259-348-8:199

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-037-3

  • Online ISBN: 978-1-59259-348-4

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