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Development of a Bioartificial Liver Device

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Book cover Tissue Engineering Methods and Protocols

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 18))

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Abstract

Liver disease continues to be a challenge clinically, with 30,000 patients dying each year from liver failure (1). Although liver transplantation can successfully treat many patients undergoing liver failure, the scarcity of donor organs severely limits this treatment’s application. For this reason, many investigators are pursuing alternatives to total organ transplantation, from living donors to cell transplantation. One additional approach is the development of a hybrid, bioartificial liver as an extracorporeal device for the temporary treatment of acute liver failure. This approach has demonstrated early success, and may provide an important clinical treatment in the near future. In addition, a bioartificial liver reactor is useful for prolonged in vitro studies of hepatocyte function. This chapter will provide information on the design and use of such a reactor for in vitro applications.

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Author information

Authors and Affiliations

  1. Department of Laboratory Medicine, University of Minnesota, Minneapolis, MN

    Linda K. Hansen

  2. Department of Pathology, University of Minnesota, Minneapolis, MN

    Linda K. Hansen

  3. the Biomedical Engineering Center, University of Minnesota, Minneapolis, MN

    Linda K. Hansen

  4. Department of Chemical Engineering and Computer Science, University of Minnesota, Minneapolis, MN

    Julie R. Friend

  5. College of Pharmacy, University of Minnesota, Minneapolis, MN

    Rory Remmel

  6. Department of Surgery and the Biomedical Engineering Center, University of Minnesota, Minneapolis, MN

    Frank B. Cerra

  7. Departments of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN

    Wei-Shou Hu

Authors
  1. Linda K. Hansen
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  2. Julie R. Friend
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  3. Rory Remmel
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  4. Frank B. Cerra
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  5. Wei-Shou Hu
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Editor information

Editors and Affiliations

  1. Center for Engineering in Medicine, Massachusetts General Hospital/Harvard Medical School, Boston, MA

    Jeffrey R. Morgan PhD  & Martin L. Yarmush MD  & 

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© 1999 Humana Press Inc., Totowa, NJ

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Hansen, L.K., Friend, J.R., Remmel, R., Cerra, F.B., Hu, WS. (1999). Development of a Bioartificial Liver Device. In: Morgan, J.R., Yarmush, M.L. (eds) Tissue Engineering Methods and Protocols. Methods in Molecular Medicine™, vol 18. Humana Press. https://doi.org/10.1385/0-89603-516-6:423

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  • DOI: https://doi.org/10.1385/0-89603-516-6:423

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-516-4

  • Online ISBN: 978-1-59259-602-7

  • eBook Packages: Springer Protocols

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