Chest
Clinical InvestigationsOxidative Stress in Obstructive Sleep Apnea
Section snippets
Subjects
A total of 128 consecutive subjects (115 men and 13 women) referred to Tenri City Hospital with suspected OSA were enrolled between March 2003 and March 2004. Their primary symptoms were excessive daytime sleepiness and snoring. All of the subjects underwent polysomnography and completed the Epworth sleepiness scale (ESS) questionnaire.16 Patients were also asked about their regular medications and smoking habits. We explained the purpose of this study and the procedures involved to the
Results
Based on the results of polysomnography, 70 subjects and 58 subjects were classified as having nonsevere OSA (including primary snoring and mild-to-moderate OSA) and severe OSA, respectively. The percentage of female subjects was significantly lower in the severe OSA group. Urinary 8-OHdG excretion was significantly higher in the severe OSA group (p = 0.03). The percentage of current smokers, BMI, and DBP were all significantly higher in the severe OSA group (p < 0.01). However, age, ESS score,
Discussion
The present study indicated that oxidative stress, as evaluated by urinary 8-OHdG excretion, was higher in severe OSA than in nonsevere OSA. Various parameters of the severity of OSA, including ODI, AHI, AI, respiratory arousal index, and T90 were significantly correlated with oxidative stress as expressed by 8-OHdG excretion. Among these parameters, ODI was most strongly correlated with oxidative stress, and the relationship survived adjustment for confounding factors that may contribute to
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