Recombinant Salmonella Expressing Burkholderia mallei LPS O Antigen Provides Protection in a Murine Model of Melioidosis and Glanders
Fig 2
Serum antibody response of BALB/c mice following intranasal immunization with S. enterica serovar Typhimurium SL3261 expressing B. mallei O antigen.
Sera were collected 4 weeks post-vaccination, and the data were analyzed by the Mann-Whitney U test. Serum IgG and IgM response to: (A) B. mallei LPS (P < 0.0001 vector vs. vaccine for IgG and IgM); (B) B. pseudomallei LPS (P < 0.0003 vector vs. vaccine for IgG, and P < 0.0079 for IgM); (C) B. thailandensis E264 lysate (P < 0.005 PBS vs. vaccine, and P < 0.0005 vector vs. vaccine). (D) Specific IgG response in the sera of intranasally-immunized BALB/c mice to B. mallei LPS or anti-B. thailandensis.