Screening of the Pan-African Natural Product Library Identifies Ixoratannin A-2 and Boldine as Novel HIV-1 Inhibitors
Fig 2
HIV-1 replication in CEM-GXR cells.
A, Flow cytometry data showing GFP expression from uninfected (top), HIV-1NL4-3-infected cells (center), and HIV-1NL4-3-infected cells plus 100 μM boldine (bottom) at Days 2 and 4. Values at the bottom-right of each panel indicate the percent GFP-positive (i.e., HIV-infected) cells. Background GFP expression is set to 0.05% in uninfected cell cultures. B, Percent infected cells, as measured by GFP expression, in cultures of CEM-GXR cells +/- HIV-1 and +/- 0.1% DMSO vehicle control. Data in B and A are from independent experiments.