The Severity of Experimental Autoimmune Cystitis Can be Ameliorated by Anti-CXCL10 Ab Treatment
Figure 3
Changes in CXCR3, CXCL9, CXCL10, CXCL11, TNF-α, IL-12p40 and IFN-γ mRNA expressions by EAC mice after anti-CXCL10 Ab treatment.
At the experimental end point, total RNA was isolated from the immune cells of iliac lymph nodes, or urinary bladder of the mice.RT-PCR analysis of unaffected group control Ab [white bar], Anti-CXCL10 Ab [gray bar], EAC induced group EAC+ control Ab [black bar], or EAC+ anti-CXCL10 Ab [striped bar] mRNA expression was performed. Fold increase in expression were expressed. Asterisk(s) (*) indicate statistically significant (p<0.05) increases between the EAC+ control Ab-treated group and the EAC group that received anti-CXCL10 Ab.