Abstract
Three different interfaces for the coupling of capillary electrophoresis with electrospray time-of-flight mass spectrometry are compared with respect to major parameters like sensitivity or robustness. The separation and detection of a test mixture of nine fluoroquinolones was employed for evaluation of these interfaces. Besides a commercially available orthogonal sheath-flow interface, an in-lab constructed in-axis sheath-flow interface (tested in two different geometrical alignments) and a simple lab-made sheathless interface were investigated. Crucial parameters like limits of detection achieved as well as ease of operation and robustness were monitored.
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Reiter, S.M., Buchberger, W. & Klampfl, C.W. Investigations on the Influence of Interface-Geometry in CE-ESI-TOF-MS. Chroma 71, 715–719 (2010). https://doi.org/10.1365/s10337-010-1504-2
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DOI: https://doi.org/10.1365/s10337-010-1504-2