Abstract
The metabolic syndrome is a group of factors associated with an increased risk of atherosclerosis and diabetes. Diabetes mellitus (DM) is classified into 2 major types - type 1 DM and type 2 DM - characterized by chronic hyperglycemia resulting from defects in insulin secretion and insulin action, respectively. Several synthetic pharmaceuticals have been developed and clinically used for treating DM; however, these pharmaceuticals continue to cause side effects. Recently, we proposed that oxovanadium(IV) (vanadyl) and zinc(II) (zinc) complexes are potent antidiabetic agents for both type 1 and type 2 DM therapy. This article reviews the vanadyl- and zinc-allixin and their related complexes that are being currently developed as novel types of antidiabetic metal complexes, focusing on their action mechanism in terms of regulation of the insulin signaling pathway and inhibition of lipolysis signaling in adipocyte cells.
Conference
International Symposium on Metallomics 2007 (ISM 2007), Nagoya, Japan, 2007-11-28–2007-12-01
References
1. doi:10.2337/diacare.27.5.1047, S. Wild, G. Roglic, A. Green, R. Sicree, H. King. Diabetes Care 27, 1047 (2004).Search in Google Scholar
2. doi:10.1038/414799a, A. R. Saltiel, C. R. Kahn. Nature 414, 806 (2001).Search in Google Scholar
3. doi:10.1038/nrm1837, C. M. Taniguchi, B. Emanuelli, C. R. Kahn. Nat. Rev. Mol. Cell Biol. 7, 96 (2006).Search in Google Scholar
4. doi:10.1016/j.tibs.2004.03.006, D. P. Brazil, Z.-Z. Yang, B. A. Hemmings. Trends Biochem. Sci. 29, 242 (2004).Search in Google Scholar
5. doi:10.1016/S0962-8924(01)02207-3, A. R. Saltiel, J. E. Pessin. Trends Cell. Biol. 12, 71 (2002).Search in Google Scholar
6. T. Kitamura, Y. Kitamura, S. Kuroda, Y. Hino, M. Ando, K. Kotani, H. Konishi, H. Matsuzaki, U. Kikkawa, W. Ogawa, M. Kasuga. Mol. Cell. Biol. 19, 6296 (1999).Search in Google Scholar
7. F. Ahmad, R. Lindh, Y. Tang, M. Weston, E. Degerman, V. C. Manganiello. Biochem. J. 404, 268 (2007).Search in Google Scholar
8. doi:10.1073/pnas.87.2.533, E. Degerman, C. J. Smith, H. Tornqvist, V. Vasta, P. Belfrage, V. C. Manganiello. Proc. Natl. Acad. Sci. USA 87, 537 (1990).Search in Google Scholar
9. H. Eriksson, M. Ridderstrale, E. Degerman, D. Ekholm, C. J. Smith, V. C. Manganiello, P. Belfrage, H. Tornqvist. Biochim. Biophys. Acta 1266, 107 (1995).10.1016/0167-4889(94)00237-9Search in Google Scholar
10. doi:10.1016/j.mrfmmm.2007.01.013, C. Devirgiliis, P. D. Zalewski, G. Perozzi, C. Murgia. Mutat. Res. 622, 81 (2007).Search in Google Scholar
11. A. H. Zargar, N. A. Shah, S. R. Massodi, B. A. Laway, F. A. Dar, A. R. Khan, F. A. Sofi, A. I. Wani. Saudi Med. J. 23, 539 (2002).Search in Google Scholar
12. doi:10.1016/S0271-5317(05)80223-4, S. Bhanot, K. H. Thompson, J. H. McNeill. Nutr. Res. 14, 593 (1994).Search in Google Scholar
13. A. H. Zargar, N. A. Shah, S. R. Massodi. Postgrad. Med. J. 74, 665 (1998).Search in Google Scholar
14. doi:10.1246/bcsj.79.1645, H. Sakurai, A. Katoh, Y. Yoshikawa. Bull. Chem. Soc. Jpn. 79, 1664 (2006).Search in Google Scholar
15. doi:10.1016/S0010-8545(01)00447-7, H. Sakurai, Y. Kojima, Y. Yoshikawa, K. Kawabe, H. Yashu. Coord. Chem. Rev. 226, 198 (2002).Search in Google Scholar
16. K. H. Thompson, C. Orvig. J. Inorg. Chem. 100, 1925 (2006).Search in Google Scholar
17. doi:10.1016/j.lfs.2005.11.008, K. Kawabe, Y. Yoshikawa, Y. Adachi, H. Sakurai. Life Sci. 78, 2866 (2006).Search in Google Scholar
18. doi:10.1016/j.lfs.2004.02.006, Y. Yoshikawa, E. Ueda, Y. Kojima, H. Sakurai. Life Sci. 75, 751 (2004).Search in Google Scholar
19. doi:10.1248/cpb.52.428, Y. Adachi, H. Sakurai. Chem. Pharm. Bull. 52, 433 (2004).Search in Google Scholar
20. doi:10.1016/j.lfs.2006.11.003, Y. Yoshikawa, Y. Adachi, H. Sakurai. Life Sci. 80, 766 (2007).Search in Google Scholar
21. doi:10.1021/jm00086a020, J. H. McNeill, V. G. Yuen, H. R. Hoveyda, C. Orvig. J. Med. Chem. 35, 1489 (1992).Search in Google Scholar
22. doi:10.1021/jm060229a, Y. Adachi, J. Yoshida, Y. Kodera, A. Katoh, J. Takada, H. Sakurai. J. Med. Chem. 49, 3256 (2006).Search in Google Scholar
23. doi:10.1007/s00775-007-0295-x, M. Hiromura, A. Nakayama, Y. Adachi, M. Doi, H. Sakurai. J. Biol. Inorg. Chem. 12, 1287 (2007).Search in Google Scholar
24. doi:10.1016/j.bbrc.2006.05.003, Y. Adachi, Y. Yoshikawa, J. Yoshida, Y. Kodera, A. Katoh, J. Takada, H. Sakurai. Biochem. Biophys. Res. Commun. 345, 950 (2006).Search in Google Scholar
25. doi:10.1038/nature05483, E. D. Rosen, B. M. Spiegelman. Nature 444, 853 (2006).Search in Google Scholar
26. doi:10.1246/cl.2005.1694, M. Yamane, Y. Adachi, Y. Toshikawa, H. Sakurai. Chem. Lett. 34, 199 (2005).Search in Google Scholar
27. doi:10.1007/s00775-004-0590-8, Y. Adachi, J. Yoshida, Y. Kodera, A. Kato, Y. Yoshikawa, Y. Kojima, H. Sakurai. J. Biol. Inorg. Chem. 9, 893 (2004).Search in Google Scholar
28. doi:10.1016/j.bbrc.2006.10.014, Y. Adachi, J. Yoshida, Y. Kodera, T. Kiss, T. Jakusch, E. A. Enyedy, Y. Yoshikawa, H. Sakurai. Biochem. Biophys. Res. Commun. 351, 170 (2006).Search in Google Scholar
29. doi:10.1038/414821a, D. E. Moller. Nature 414, 827 (2001).Search in Google Scholar
30. doi:10.1038/nrd2005, S. M. Grundy. Nat. Rev. Drug Discov. 5, 309 (2006).Search in Google Scholar
31. doi:10.1007/s00775-008-0352-0, A. Nakayama, M. Hiromura, Y. Adachi, H. Sakurai. J. Biol. Inorg. Chem. 13, 675 (2008).Search in Google Scholar
32. doi:10.1258/0004563054889990, M. Ghayour-Mobarhan, A. Taylor, S. A. New, D. J. Lamb, G. A. Ferns. Ann. Clin. Biochem. 42, 375 (2005).Search in Google Scholar
33. doi:10.1007/s10741-006-9189-1, N. Cohen, A. Golik. Heart Fail. Rev. 11, 24 (2006).Search in Google Scholar
34. W. Wu, X. Wang, W. Zhang, W. Reed, J. M. Samet, Y. E. Whang, A. J. Ghio. J. Biol. Chem. 278, 28263 (2003).Search in Google Scholar
35. doi:10.1038/nrd2007, D. F. Lazar, A. R. Saltiel. Nat. Rev. Drug Discov. 5, 342 (2006).Search in Google Scholar
36. doi:10.1016/j.jinorgbio.2006.12.015, W. Basuki, M. Hiromura, H. Sakurai. J. Inorg. Biochem. 101, 699 (2007).Search in Google Scholar
37. K. N. Frayn. Diabetologia 45, 1210 (2002).10.1007/s00125-002-0873-ySearch in Google Scholar
38. doi:10.1046/j.1365-2362.32.s3.3.x, G. Boden, G. I. Shulman. Eur. J. Clin. Invest. 32, 23 (2002).Search in Google Scholar
39. doi:10.1016/j.cellsig.2005.08.009, G. Y. Carmen, S. M. Victor. Cell Signal 18, 408 (2006).Search in Google Scholar
40. doi:10.1016/0014-5793(95)92711-I, K. Fukui, H. Ohya-Nishiguchi, M. Nakai, H. Sakurai, H. Kamada. FEBS Lett. 368, 31 (1995).Search in Google Scholar
41. doi:10.1016/S0162-0134(99)00204-4, K. Fukui, Y. Fujisawa, H. Ohya-Nishiguchi, H. Kamada, H. Sakurai. J. Inorg. Biochem. 77, 215 (1999).Search in Google Scholar
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