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Publicly Available Published by De Gruyter January 1, 2009

Investigations toward new lead compounds from medicinally important plants

  • Ashok K. Prasad , Vineet Kumar , Pragya Arya , Sarvesh Kumar , Rajesh Dabur , Naresh Singh , Anil K. Chhillar , Gainda L. Sharma , Balaram Ghosh , Jesper Wengel , Carl E. Olsen and Virinder S. Parmar
From the journal Pure and Applied Chemistry
https://doi.org/10.1351/pac200577010025
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Abstract

Extensive phytochemical investigations on 30 Piper species growing in India and other medicinal plants have revealed the presence of a large number of novel compounds belonging to different classes. The antiviral activity of several lignans and neolignans belonging to different structural types has been evaluated against six different viral strains. Further, the effects of ethanol, chloroform, and hexane extracts of Piper longum and Piper galiatum on TNF-α induced expression of intercellular adhesion molecule-1 (ICAM-1) on human umbilical vein endothelial cells have been studied, a novel aromatic ester was isolated from the most active extract of P. longum. A potential antifungal compound having implications in treating aspergillosis was isolated from an important Indian medicinal plant, Datura metel.

Keywords: antifungal activity; anti-inflammatory activity; aspergillosis; ICAM-1 inhibition; lignans; long-chain esters and amides; medicinal plants; neolignans; piper species

Conference

International Symposium on the Chemistry of Natural Products and the 4th International Congress on Biodiversity, International Conference on Biodiversity, International Symposium on the Chemistry of Natural Products, ICOB, ISCNP, Biodiversity, Natural Products, 24th, Delhi, India, 2004-01-26–2004-01-31

Published Online: 2009-01-01
Published in Print: 2005-01-01

© 2013 Walter de Gruyter GmbH, Berlin/Boston

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From the journal
Pure and Applied Chemistry
Pure and Applied Chemistry
Volume 77 Issue 1
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