Chemoselective reactions: Toward the synthesis of biologically active natural products with anticancer activities

Sébastien Reymond; Laurent Ferrié; Amandine Guérinot; Patrice Capdevielle; Janine Cossy

doi:10.1351/pac200880081683

Publicly Available Published by De Gruyter January 1, 2009

Chemoselective reactions: Toward the synthesis of biologically active natural products with anticancer activities

Sébastien Reymond , Laurent Ferrié , Amandine Guérinot , Patrice Capdevielle and Janine Cossy

From the journal Pure and Applied Chemistry

https://doi.org/10.1351/pac200880081683

Abstract

Leucascandrolide A and migrastatin were synthesized efficiently by using chemoselective reactions such as olefin metatheses. The use of an iron-catalyzed cross-coupling reaction overcame difficulties encountered with palladium-catalyzed processes in our synthetic approach toward spirangien A.

Keywords: allyltitanation; chemoselective reactions; cross-coupling; cross-metathesis; crotyltitanation; iron; natural products; ring-closing metathesis; total synthesis

Conference

IUPAC World Chemistry Congress, IUPAC Congress, CONGRESS, IUPAC Congress, 41st, Turin, Italy, 2007-08-05–2007-08-11

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Published Online: 2009-01-01

Published in Print: 2008-01-01

Chemoselective reactions: Toward the synthesis of biologically active natural products with anticancer activities

Abstract

Conference

References

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