Effects of ShouTaiWan on the MAPK Signal Transduction Pathway of CD4+T Cells in Maternal-fetal Interface of Mice with Recurrent Spontaneous AbortionChinese Full Text
YOU Zhao-ling,HE Dong-mei,LIU Hui-ping,LAI Mao-hua,LU Fang-guo,LEI Lei(Hunan University of Chinese Medicine,Changsha 410007,Hunan,China)
Abstract: Objective:To study the effects of ShouTaiWan on the MAPK signal transduction pathway of CD4+T cells in maternal-fetal interface of mice with recurrent spontaneous abortion（RSA）.Methods:CBA/J BALB/C mating combination and CBA/J DBA/2 mating combination were used as Normal pregnancy and RSA model respectively.Mice with RSA were randomly assigned to model group and ShouTaiWan group. After 14 days of administration,the MAPK signal transduction pathway of CD4+T cells in mice decidual and placental tissues were detected by Springbio720 antibody microarrays.Results:ShouTaiWan could increased the Phosphorylation level of Raf1、A-Raf、Ask1、Mek1、Mek2、JKK1、ERK1、ERK2、c-fos、c-Jun and CREB protein in the MAPK signal transduction pathway （≥1.5）.At the same time,ShouTaiWan could decrease the Phosphorylation level of MEK6 protein. Conclusion:The activation of ERK and JNK signal transduction pathway might play a important role in the therapy of RSA by ShouTaiWan.
- DOI：
10.13193/j.archtcm.2010.03.12.youzhl.031
- Series：
- Subject：
- Classification Code：
R285.5
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