Open Access, Peer-reviewed
pISSN 2287-2892
eISSN 2288-2561
    J Lipid Atheroscler. 2014 Dec;3(2):79-87. Korean.
    Published online Dec 31, 2014.
    https://doi.org/10.12997/jla.2014.3.2.79
    © 2014 The Korean Society Lipidology and Atherosclerosis.
    Original Article

    Comparison of Coronary Plaque and Stenosis Between Coronary Computed Tomography Angiography and Virtual Histology-Intravascular Ultrasound in Asymptomatic Patients with Risk Factors for Coronary Artery Disease

    Young Joon Hong,1 Myung Ho Jeong,1 Yun Ha Choi,1 Soo Young Park,1 Hyun Ju Seon,2 Hyun Sung Lee,2 Yun Hyun Kim,2 Sang Cheol Cho,1 Jae Young Cho,1 Hae Chang Jeong,1 Soo Young Jang,1 Jong Hyun Yoo,1 Ji Eun Song,1 Ki Hong Lee,1 Keun Ho Park,1 Doo Sun Sim,1 Nam Sik Yoon,1 Hyun Ju Yoon,1 Kye Hun Kim,1 Hyung Wook Park,1 Ju Han Kim,1 Youngkeun Ahn,1 Jeong Gwan Cho,1 Jong Chun Park,1 and Jung Chaee Kang1
      • 1Department of Cardiology, Chonnam National University Hospital, Gwangju, Korea.
      • 2Department of Radiology, Chonnam National University Hospital, Gwangju, Korea.
    • Corresponding Author: Myung Ho Jeong, Department of Cardiology, Chonnam National University Hospital, 42 Jaebong-ro, Donggu, Gwangju 501-757, Korea. Tel: +82-62-220-6243, Fax: +82-62-228-7174, Email: myungho@chollian.net
    Received July 14, 2014; Revised September 11, 2014; Accepted October 16, 2014.

    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Abstract

    Objectives

    The purpose of the study was to compare plaque characteristics by coronary computed tomography angiography (CCTA) with those by virtual histology-intravascular ultrasound (VH-IVUS).

    Methods

    We enrolled 50 asymptomatic patients with diabetes mellitus or more than two risk factors for coronary artery disease such as hypertension, smoking, and hyperlipidemia. If the patient had a coronary lesion (plaque with more than 50% stenosis or calcium score more than 100), we recommended coronary angiography and VH-IVUS and compared CCTA findings with VH-IVUS findings.

    Results

    35 patients (70%) had coronary lesions, and we performed both CCTA and VH-IVUS in 23 patients. All 23 patients had multiple risk factors, and the majority of target lesions were located at left anterior descending artery (73.9%), and calcium score of lesion site was 106±162 with plaque volume of 232±153 mm3 by CCTA. Calcium score of lesion site was significantly greater in diabetic patients (n=14) than non-diabetic patients (n=9) (118±159 vs. 88±175, p=0.038). By VH-IVUS, plaque volume was 174±127 mm3, absolute necrotic core (NC) volume was 22±21 mm3, and relative NC volume was 20.8±8.7%. Absolute dense calcium (DC) volume and absolute NC volumes were significantly greater in diabetic patients than non-diabetic patients (11.5±13.8 mm3 vs. 9.1±11.0 mm3,p=0.028, and 23.9±24.7 mm3 vs. 18.1±14.3 mm3,p=0.035, respectively). Plaque volume by CCTA correlated with that of VH-IVUS (r=0.742, p<0.001), and plaque volume by CCTA correlated with absolute NC volume by VH-IVUS (r=0.621, p<0.001), and calcium score of lesion site by CCTA correlated with absolute dense calcium volume by VH-IVUS (r=0.478, p=0.028).

    Conclusion

    Coronary lesion was detected by CCTA in 70% of asymptomatic patients with multiple coronary risk factors, and parameters detected by CCTA correlated well with those detected by VH-IVUS.

    Keywords
    Subclinical atherosclerosis; Plaque; Computed tomography; Virtual histology-intravascualr ultrasound

    Figures

    Fig. 1
    Coronary computed tomography angiography (A), coronary angiography (B), and virtual histology-intravascular ultrasound findings (C) in patients with diabetes mellitus, hypertension, smoking, and hyperlipidemia.

    Fig. 2
    Correlation between plaque volume by coronary computed tomography angiography (CCTA) with that by virtual histology-intravascular ultrasound (VH-IVUS) (A), and correlation between plaque volume by CCTA with absolute necrotic core volume by VH-IVUS (B), and correlation between lesion site calcium score by CCTA with absolute dense calcium volume by VH-IVUS (C).

    Tables

    Table 1
    Baseline characteristics in patients who underwent both computed tomography angiography and virtual histology-intravascular ultrasound

    Table 2
    Computed tomography angiography and quantitative coronary angiography findings in patients who underwent both computed tomography angiography and virtual histology-intravascular ultrasound

    Table 3
    Virtual histology-intravascular ultrasound findings in patients who underwent both computed tomography angiography and virtual histology-intravascular ultrasound

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    MeSH Terms
    Angiography*
    Arteries
    Calcium
    Constriction, Pathologic*
    Coronary Angiography
    Coronary Artery Disease*
    Diabetes Mellitus
    Humans
    Hyperlipidemias
    Hypertension
    Risk Factors*
    Smoke
    Smoking
    Ultrasonography*
    Metrics
    Share
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    Tables
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