Abstract
We report that the cubic octameric polyhedral oligomeric silsesquioxanes (POSS)-core dendrimers, novel gadolinium (Gd) chelators, enhanced the proton relaxivity to Gd3+. The stability of the Gd complex with POSS(G1.5) was similar to those of DOTA and DTPA. From the MTT assay with the primary hepatocytes, the cytotoxicity of [Gd2POSS(G1.5)]2− showed lower than that of the [Gd(DOTA)]− complex. The detection limits were approximately 100-fold improved than those of DOTA and DTPA-Gd complexes in the MR images.
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Tanaka, K., Kitamura, N., Naka, K. et al. Improving Proton Relaxivity of Dendritic MRI Contrast Agents by Rigid Silsesquioxane Core. Polym J 41, 287–292 (2009). https://doi.org/10.1295/polymj.PJ2008274
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DOI: https://doi.org/10.1295/polymj.PJ2008274
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