The role of gut microbiota in non-alcoholic fatty liver disease: pathways of mechanisms

Chyntia Olivia Maurine JASIRWAN; Cosmas Rinaldi Adithya LESMANA; Irsan HASAN; Andri Sanityosos SULAIMAN; Rino Alvani GANI

doi:10.12938/bmfh.18-032

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The role of gut microbiota in non-alcoholic fatty liver disease: pathways of mechanisms

Chyntia Olivia Maurine JASIRWAN, Cosmas Rinaldi Adithya LESMANA, Irsan HASAN, Andri Sanityosos SULAIMAN, Rino Alvani GANI

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Keywords: gut microbiota, dysbiosis, NAFLD, inflammatory pathway, metabolic pathway

JOURNAL FREE ACCESS

2019 Volume 38 Issue 3 Pages 81-88

DOI https://doi.org/10.12938/bmfh.18-032

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Abstract

Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Its prevalence increases with increasing rates of obesity, insulin resistance, and diabetes mellitus. The pathogenesis of NAFLD involves many factors, including the gastrointestinal microbiota. However, there is still debate about the impact of gut dysbiosis in the NAFLD disease progression. Therefore, this paper aims to review the relationship between gut microbiota and other risk factors for NAFLD and how gut dysbiosis plays a role in the pathogenesis of NAFLD. Hopefully, this paper can make an appropriate contribution to the development of NAFLD research in the future.

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