A study of the prebiotic effect of lactulose at low dosages in healthy Japanese women

Yohei SAKAI; Nobuo SEKI; Hirokazu HAMANO; Hiroshi OCHI; Fumiaki ABE; Fumiko SHIMIZU; Kazuya MASUDA; Hisakazu IINO

doi:10.12938/bmfh.18-013

Note

A study of the prebiotic effect of lactulose at low dosages in healthy Japanese women

Yohei SAKAI, Nobuo SEKI, Hirokazu HAMANO, Hiroshi OCHI, Fumiaki ABE, Fumiko SHIMIZU, Kazuya MASUDA, Hisakazu IINO

Author information

Yohei SAKAI
Food Ingredients & Technology Institute, R&D Division, Morinaga Milk Industry Co., Ltd., Kanagawa 252-8583, Japan
Nobuo SEKI
Food Ingredients & Technology Institute, R&D Division, Morinaga Milk Industry Co., Ltd., Kanagawa 252-8583, Japan
Hirokazu HAMANO
R&D Management Department, Morinaga Milk Industry Co., Ltd., Kanagawa 252-8583, Japan
Hiroshi OCHI
Food Ingredients & Technology Institute, R&D Division, Morinaga Milk Industry Co., Ltd., Kanagawa 252-8583, Japan
Fumiaki ABE
Food Ingredients & Technology Institute, R&D Division, Morinaga Milk Industry Co., Ltd., Kanagawa 252-8583, Japan
Fumiko SHIMIZU
Department of Food Science and Nutrition, Faculty of Life and Environmental Sciences, Showa Women’s University, Tokyo 154-8533, Japan
Kazuya MASUDA
Department of Food Science and Nutrition, Faculty of Life and Environmental Sciences, Showa Women’s University, Tokyo 154-8533, Japan
Hisakazu IINO
Life Science for Living System, Graduate School, Showa Women’s University, Tokyo 154-8533, Japan

Keywords: indigestible oligosaccharide, gut microbiome, constipation, intestinal regulation

JOURNAL FREE ACCESS

2019 Volume 38 Issue 2 Pages 69-72

DOI https://doi.org/10.12938/bmfh.18-013

Browse “Advance online publication” version

Details

Abstract

To investigate the prebiotic effect of lactulose at low dosages, we assessed changes in defaecation frequency following ingestion of 1, 2, or 3 g/day of lactulose for 2 weeks. Each test was carried out after a 2-week washout period. This was an open-label, before-after trial that enrolled 26 healthy Japanese women. The defaecation frequency, number of defaecation days, and number of faecal bifidobacteria increased significantly compared with before ingestion of 1, 2, and 3 g/day of lactulose. These results suggest that even 1 g/day of lactulose could have a prebiotic effect.

Corresponding author

Register with J-STAGE for free!