Comparative evaluation of the efficacy of commercial and prototype PRRS subunit vaccines against an HP-PRRSV challenge

Do Tien DUY; Hanjin KIM; Jiwoon JEONG; Kee Hwan PARK; Siyeon YANG; Taehwan OH; Seeun KIM; Ikjae KANG; Chanhee CHAE

doi:10.1292/jvms.17-0583

Virology

Comparative evaluation of the efficacy of commercial and prototype PRRS subunit vaccines against an HP-PRRSV challenge

Do Tien DUY, Hanjin KIM, Jiwoon JEONG, Kee Hwan PARK, Siyeon YANG, Taehwan OH, Seeun KIM, Ikjae KANG, Chanhee CHAE

Author information

Do Tien DUY
Faculty of Animal Husbandry and Veterinary Medicine, Nonglam University, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, Vietnam
Hanjin KIM
Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea
Jiwoon JEONG
Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea
Kee Hwan PARK
Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea
Siyeon YANG
Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea
Taehwan OH
Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea
Seeun KIM
Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea
Ikjae KANG
Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea
Chanhee CHAE
Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea

Keywords: highly pathogenic porcine reproductive and respiratory syndrome virus, porcine reproductive and respiratory syndrome, subunit vaccine

JOURNAL FREE ACCESS

2018 Volume 80 Issue 9 Pages 1463-1467

DOI https://doi.org/10.1292/jvms.17-0583

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Abstract

The objective of this study was to compare the efficacy of a commercial porcine reproductive and respiratory syndrome (PRRS) subunit vaccine and a prototype PRRS II subunit vaccine against a highly pathogenic PRRS virus (HP-PRRSV) in pigs. Both vaccines were administered intramuscularly in 2 doses at 21 and 42 days of age, and the pigs were challenged intranasally with HP-PRRSV at 63 days of age. Pigs vaccinated with the prototype PRRS II subunit vaccine had significantly higher anti-PRRSV antibody titers, a greater number of interferon-γ-secreting cells, and a greater reduction in lung lesion scores compared to pigs vaccinated with the commercial PRRS subunit vaccine. Therefore, the commercial PRRS subunit and prototype PRRS II subunit vaccines are efficacious against HP-PRRSV.

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