The Noc proteins involved in ribosome synthesis and export contain divergent HEAT repeats
Abstract
The Noc1–4p proteins were previously reported to be involved in intranuclear and nucleocytoplasmic transport of pre-ribosomes. Using fold recognition and structural modeling, we show that Noc1–4p are largely comprised of α-helical repeats similar to HEAT repeats. Because other HEAT-repeat proteins play key roles in transport processes, this finding provides a plausible mechanistic explanation for the function of the Noc proteins.
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Footnotes
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Article and publication are at http://www.rnajournal.org/cgi/doi/10.1261/rna.5184704.
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- Accepted December 10, 2003.
- Received October 1, 2003.
- Copyright 2004 by RNA Society