HnRNP L represses cryptic exons
- 1Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6059, USA
- 2Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2196, USA
- Corresponding author: jling{at}jhu.edu
Abstract
The fidelity of RNA splicing is regulated by a network of splicing enhancers and repressors, although the rules that govern this process are not yet fully understood. One mechanism that contributes to splicing fidelity is the repression of nonconserved cryptic exons by splicing factors that recognize dinucleotide repeats. We previously identified that TDP-43 and PTBP1/PTBP2 are capable of repressing cryptic exons utilizing UG and CU repeats, respectively. Here we demonstrate that hnRNP L (HNRNPL) also represses cryptic exons by utilizing exonic CA repeats, particularly near the 5′SS. We hypothesize that hnRNP L regulates CA repeat repression for both cryptic exon repression and developmental processes such as T cell differentiation.
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Article is online at http://www.rnajournal.org/cgi/doi/10.1261/rna.065508.117.
- Received December 29, 2017.
- Accepted March 21, 2018.
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