What will the future hold: RNP quality control and degradation
- Department of Cancer Biology, The Scripps Research Institute, Jupiter, Florida 33458, USA
- Corresponding author: kkarbst{at}scripps.edu
This extract was created in the absence of an abstract.
Many will agree that the discovery of regulatory RNA molecules (miRNAs, piRNAs, lncRNAs, crRNAs, etc.) and the technological advances made possible through these basic scientific findings, are the biggest discoveries in the RNA world, and perhaps in the biosciences as a whole since the inception of the RNA journal. However, this kind of agreement is unlikely in regards to what the most important outstanding questions are. Perhaps these questions are unforeseeable, just like the discovery of entirely new classes of RNA molecules with diverse regulatory functions, conserved in all forms of life was unanticipated. Thus, I will instead discuss a problem I believe is interesting, exciting and important, without trying to claim that its solution will be game-changing: I believe that a critical open question in RNA biology is the elucidation of quality control and connected degradation pathways for nascent and damaged RNA–protein complexes.
There are many possible mechanisms for …
