Isolation of Nabscessin C from Nocardia abscessus IFM 10029T and a Study on Biosynthetic Pathway for Nabscessins

Shoko Hara; Yasumasa Hara; Midori A. Arai; Yoko Kusuya; Hiroki Takahashi; Takashi Yaguchi; Masami Ishibashi

doi:10.1248/cpb.c18-00430

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Isolation of Nabscessin C from Nocardia abscessus IFM 10029^T and a Study on Biosynthetic Pathway for Nabscessins

Shoko Hara, Yasumasa Hara, Midori A. Arai, Yoko Kusuya, Hiroki Takahashi, Takashi Yaguchi, Masami Ishibashi

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Keywords: actinomycete, Nocardia, aminocyclitol, biosynthetic pathway

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Supplementary material

2018 Volume 66 Issue 10 Pages 976-982

DOI https://doi.org/10.1248/cpb.c18-00430

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Abstract

A new aminocyclitol derivative, designated nabscessin C (1), was isolated from Nocardia abscessus IFM 10029^T. Nabcessin C is an isomer of nabscessins A (2) and B (3) with different positioning of the acyl group. Absolute configuration of nabscessin A was determined by conversion into the 2-deoxy-scyllo-inosamine pentaacetyl derivative (4) by hydrolysis and acetylation of 2. The biosynthetic pathway of nabscessins is proposed based on gene expression analysis.

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