Concise Synthesis of Hydroxy β-Methyl Fatty Acid Ethyl Esters

Yuki Sakai; Yukiko Asakura; Mitsuhiro Morita; Takashi Takahashi

doi:10.1248/cpb.c17-00637

Notes

Concise Synthesis of Hydroxy β-Methyl Fatty Acid Ethyl Esters

Yuki Sakai, Yukiko Asakura, Mitsuhiro Morita, Takashi Takahashi

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Keywords: β-methyl fatty acid, chemical synthesis, Johnson–Claisen rearrangement, hydroxy fatty acid

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2017 Volume 65 Issue 12 Pages 1195-1198

DOI https://doi.org/10.1248/cpb.c17-00637

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Abstract

Hydroxy β-methyl fatty acid ethyl esters bearing different carbon chain lengths and varying hydroxyl group positions were successfully synthesized from symmetric diols. These fatty acid derivatives are useful intermediates of chemical probes for metabolic analyses of fatty acid.

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