Cytotoxic Homoisoflavonoids from Ophiopogon japonicus Tubers

Nguyen Hai Dang; Nguyen Dinh Chung; Ha Manh Tuan; Nguyen Tuan Hiep; Nguyen Tien Dat

doi:10.1248/cpb.c16-00743

Notes

Cytotoxic Homoisoflavonoids from Ophiopogon japonicus Tubers

Nguyen Hai Dang, Nguyen Dinh Chung, Ha Manh Tuan, Nguyen Tuan Hiep, Nguyen Tien Dat

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Keywords: Ophiopogon japonicus, homoisoflavanone, homoisoflavane, homoisopogon, cytotoxicity

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Supplementary material

2017 Volume 65 Issue 2 Pages 204-207

DOI https://doi.org/10.1248/cpb.c16-00743

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Abstract

A phytochemical fractionation of a methanol extract of Ophiopogon japonicus tubers led to the isolation of a new homoisoflavanone, homoisopogon A (1), and three new homoisoflavanes, homoisopogon B–D (2–4). Their chemical structures were elucidated by mass, NMR, and circular dichroism (CD) spectroscopic methods. Homoisopogon A (1) exhibited potent cytotoxicity against human lung adenocarcinoma LU-1, human epidermoid carcinoma KB, and human melanoma SK-Mel-2 cancer cells with IC₅₀ values ranging from 0.51 to 0.66 µM.

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