Plantagiolides I and J, Two New Withanolide Glucosides from Tacca plantaginea with Nuclear Factor-kappaB Inhibitory and Peroxisome Proliferator-Activated Receptor Transactivational Activities

Tran Hong Quang; Nguyen Thi Thanh Ngan; Chau Van Minh; Phan Van Kiem; Pham Hai Yen; Bui Huu Tai; Nguyen Xuan Nhiem; Nguyen Phuong Thao; Hoang Le Tuan Anh; Bui Thi Thuy Luyen; Seo Young Yang; Young Ho Kim

doi:10.1248/cpb.c12-00550

Regular Articles

Plantagiolides I and J, Two New Withanolide Glucosides from Tacca plantaginea with Nuclear Factor-kappaB Inhibitory and Peroxisome Proliferator-Activated Receptor Transactivational Activities

Tran Hong Quang, Nguyen Thi Thanh Ngan, Chau Van Minh, Phan Van Kiem, Pham Hai Yen, Bui Huu Tai, Nguyen Xuan Nhiem, Nguyen Phuong Thao, Hoang Le Tuan Anh, Bui Thi Thuy Luyen, Seo Young Yang, Young Ho Kim

Author information

Tran Hong Quang
College of Pharmacy, Chungnam National University
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Thi Thanh Ngan
College of Pharmacy, Chungnam National University
Chau Van Minh
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Phan Van Kiem
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Pham Hai Yen
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Bui Huu Tai
College of Pharmacy, Chungnam National University
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Xuan Nhiem
College of Pharmacy, Chungnam National University
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Phuong Thao
College of Pharmacy, Chungnam National University
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Hoang Le Tuan Anh
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Bui Thi Thuy Luyen
College of Pharmacy, Chungnam National University
Seo Young Yang
College of Pharmacy, Chungnam National University
Young Ho Kim
College of Pharmacy, Chungnam National University

Keywords: Tacca plantaginea, withanolide glucoside, plantagiolide, nuclear factor-kappaB-luciferase assay, peroxisome proliferator response element-luciferase assay, GAL-4-peroxisome proliferator-activated receptor chimera assay

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Supplementary material

2012 Volume 60 Issue 12 Pages 1494-1501

DOI https://doi.org/10.1248/cpb.c12-00550

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Abstract

A novel withanolide glucoside, plantagiolide I (1), a new withanolide glucoside, plantagiolide J (2), and six known compounds (3–8) were isolated from the whole plant of Tacca plantaginea. Their structures were determined by spectroscopic and chemical methods. Compound 3 significantly inhibited tumor necrosis factor alpha (TNFα)-induced nuclear factor-kappaB (NF-κB) transcriptional activity in HepG2 cells in a dose-dependent manner, with IC₅₀ values of 9.0 µM. Compounds 1–8 enhanced the transcriptional activity of peroxisome proliferator-activated receptors (PPARs) in a dose-dependent manner, with EC₅₀ values ranging from 1.6 to 49.7 µM. In addition, the transactivational effects of compounds 1–8 on three individual PPAR subtypes, including PPARα, β(δ), and γ were evaluated. Compounds 1–8 significantly activated the transcriptional activity of PPARβ(δ), with EC₅₀ values in a ranging from 4.1 to 29.6 µM. These results provide scientific support for the use of T. plantaginea and its components for the prevention and treatment of inflammatory and metabolic diseases.

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