Simultaneous Dissolution of Naproxen and Flurbiprofen from a Novel Ternary γ-Cyclodextrin Complex

Kenjirou Higashi; Saori Ideura; Haruka Waraya; Waree Limwikrant; Kunikazu Moribe; Keiji Yamamoto

doi:10.1248/cpb.58.769

Communicatins to the Editor

Simultaneous Dissolution of Naproxen and Flurbiprofen from a Novel Ternary γ-Cyclodextrin Complex

Kenjirou Higashi, Saori Ideura, Haruka Waraya, Waree Limwikrant, Kunikazu Moribe, Keiji Yamamoto

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Keywords: cyclodextrin, dissolution, powder X-ray diffraction, sealed-heating, inclusion complex

JOURNAL FREE ACCESS

2010 Volume 58 Issue 5 Pages 769-772

DOI https://doi.org/10.1248/cpb.58.769

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Abstract

A crystalline ternary complex was prepared by sealed-heating of naproxen (NPX) with a flurbiprofen (FBP)/γ-cyclodextrin (γ-CD) inclusion complex. The dissolution rates of NPX and FBP in the ternary complex were almost the same, indicating that FBP and NPX from the complex dissolved simultaneously. The ternary CD complex showing a fascinating dissolution property could be a new formulation for combination therapies.

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