Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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A New Monoterpenoid Glycoside from Myrica esculenta and the Inhibition of Angiotensin I-Converting Enzyme
Nguyen Xuan Nhiem, Phan Van Kiem, Chau Van Minh, Bui Huu Tai, Nguyen Xuan Cuong, Vu Kim Thu, Hoang Le Tuan Anh, Sung-Hoon Jo, Hae-Dong Jang, Young-In Kwon, Young Ho Kim
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Keywords: Myrica esculenta, myresculoside, angiotensin I-converting enzyme inhibitor, antihypertensive
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2010 Volume 58 Issue 10 Pages 1408-1410

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Abstract

One new monoterpenoid glycoside, myresculoside (1), and eleven known compounds, were isolated from methanol extract of Myrica esculenta leaves by repeated column chromatography. The effects of these compounds on angiotensin I-converting enzyme (ACE) inhibition were investigated. Compounds 3 and 4 showed the most potent ACE inhibition with rates of 29.97% and 25.63% at concentration of 100 μM, respectively. Compounds 5, 6, and 11 showed weak activity with inhibitory rates of 0.07—1.41% at concentration of 100 μM.

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© 2010 The Pharmaceutical Society of Japan
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