Synthesis of 2-Oxo/Thioxooctahydroquinazolin-5-one Derivatives and Their Evaluation as Anticancer Agents

Mazaahir Kidwai; Divya Bhatnagar; Rakesh Kumar; Pratibha Mehta Luthra

doi:10.1248/cpb.58.1320

Regular Articles

Synthesis of 2-Oxo/Thioxooctahydroquinazolin-5-one Derivatives and Their Evaluation as Anticancer Agents

Mazaahir Kidwai, Divya Bhatnagar, Rakesh Kumar, Pratibha Mehta Luthra

Author information

Keywords: Ceric ammonium nitrate, polyethylene glycol, U87 human glioma cell, 2-oxo/thioxooctahydroquinazolin-5-one

JOURNAL FREE ACCESS

2010 Volume 58 Issue 10 Pages 1320-1323

DOI https://doi.org/10.1248/cpb.58.1320

Details

Abstract

An environment friendly method for the synthesis of 2-oxo/thioxooctahydroquinazolin-5-one derivatives has been devised using Ceric ammonium nitrate (CAN) as catalyst and polyethylene glycol (PEG) as solvent. The cytotoxic effect of these compounds was studied on U87 human glioma cells, compounds 4c, 4d and 4e are found to exhibit excellent activity at a concentration as low as 0.06 μg/ml.

Corresponding author

Register with J-STAGE for free!